Hop Downy Mildew (caused by Pseudoperonospora humuli) is specific to hops (Humulus lupulus. The disease is the single most devastating disease in Western United States hopyards, since the fungus thrives in moist climates. Infected young hop bines become stunted with thickened clusters of pale curled leaves. These spikes have a silvery upper surface, while the undersides of leaves become blackened with spores. These dwarfed spikes are called "basal spikes". 'Lateral' or 'terminal' spikes occur further up the bine. An entire hop crop could be devastated in only a few days.
Similarly, cucurbit downy mildew (caused by Pseudoperonospora cubensis) is specific to cucurbits (e.g., cantaloupe, cucumber, pumpkin, squash, watermelon and other members of the Cucurbitaceae/gourd family). The disease is one of the most important diseases of cucurbits worldwide.