FRC is the sum of Expiratory Reserve Volume (ERV) and Residual Volume (RV) and measures approximately 2400 ml in a 70 kg, average-sized male. It can be estimated through spirometry, but in order to measure it more precisely, one would need to perform a test that directly measures RV such as nitrogen washout, helium dilution or body plethysmography.
A lowered or elevated FRC is often an indication of some form of respiratory disease. For instance, in emphysema, the lungs are more compliant and therefore are more susceptible to the outward recoil forces of the chest wall. Emphysema patients often have noticeably broader chests because they are breathing at larger volumes.