Specifically, fructokinase may also regulate starch synthesis in conjunction with SS, sucrose synthase, which first metabolizes sink tissue in plant tissues such as in potatoes. There are also two divergent fructokinase genes that are differentially expressed and which also have different enzymatic properties such as those found in tomatoes. In tomatoes, fructokinase 1 (Frk 1) mRNA is expressed at a constant level during fruit development. However, fructokinase 2 (Frk 2) mRNA has a high expression level in young tomato fruit but then decreases during the later stages of fruit development. Frk 2 has a higher affinity for fructose than Frk 1 but Frk 2 activity is inhibited by high levels of fructose, whereas Frk 1 activity is not.
In Rhizobium meliloti, a common gram-soil bacterium, fructokinase is also used in the metabolism of mannitol and sorbitol, in addition to the metabolism of fructose.
In human liver, purified fructokinase, when coupled with aldolase, has been discovered to contribute to an alternative mechanism to produce oxalate from xylitol. In coupled sequence, fructokinase and aldolase produce glycolaldehyde, a precursor to oxalate, from D-xylulose via D-xylulose 1-phosphate.
In rat liver cells (hepatocytes), GTP is also a substrate of fructokinase. It can be used at a substantial rate by fructokinase. In these isolated hepatocytes, in vivo, when the concentration of ATP falls to about 1 millimole in a short time interval, GTP becomes an important substrate under these specific conditions.
ATP + D-Fructose = ADP + D-Fructose 6-phosphate
Fructosuria or hepatic fructokinase deficiency is a rare but benign inherited metabolic disorder. This condition is caused by a deficiency of fructokinase in the liver. Affected individuals usually display a large blood fructose concentration after the ingestion of fructose, sucrose or sorbitol. The disease is mainly characterized by the detection of the abnormal excretion of fructose in the urine through a urinalysis. Fructokinase is needed for the synthesis of glycogen, the body's form of stored energy, from fructose. The presence of fructose in the blood and urine may lead to an incorrect diagnosis of diabetes mellitus. Symptoms that may lead to the eventual diagnosis of fructosuria are hepatic fructokinase deficiency, levulosuria and ketohexokinase deficiency.
Wipo Publishes Patent of Cj Cheiljedang, Hyun Won Bae, Hyung Joon Kim, Jun OK Moon, Jae Woo Jang, Jong Chul Kim, Tae Han Kim, Jin Suck Sung, Kyung Han Lee, Dae Cheol Kim, Hyo Jin Kim, Hyun Ae Bae, Sang Jo Lim for "Corynebacterium Sp. Transformed with a Fructokinase Gene Derived from Escherichia Sp. and Process for Preparing L-Amino Acid Using the Same" (South Korean Inventors)
Oct 09, 2012; GENEVA, Oct. 9 -- Publication No. WO/2012/134253 was published on Oct. 4. Title of the invention: "CORYNEBACTERIUM SP....
WIPO PUBLISHES PATENT OF THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE FOR "METHODS AND COMPOSITIONS FOR THE INHIBITION OF FRUCTOKINASE" (AMERICAN INVENTORS)
Feb 10, 2012; GENEVA, Feb. 10 -- Publication No. WO/2012/019188 was published on Feb. 09. Title of the invention: "METHODS AND COMPOSITIONS FOR...
Research on Phosphotransferases (Alcohol Group Acceptor) Detailed by Scientists at Max Planck Institute for Molecular Plant Physiology.
May 24, 2011; A new study, "Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence...