10-Formyl-tetrahydrofolate (10-CHO-THF) is form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions. This is important in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase.
10-CHO-THF is produced by the enzymes methenyltetrahydrofolate cyclohydrolase and formate-tetrahydrofolate ligase. It can be converted back into tetrahydrofolate and formate by formyltetrahydrofolate deformylase.
Publication No. WO/2010/064437 Published on June 10, Assigned to Kaneka for Formyl Group-Containing Porous Support, Adsorbent, Production Method (Japanese Inventors)
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WIPO PUBLISHES PATENT OF OSAKA UNIVERSITY FOR "PROCESS FOR PRODUCTION OF 5-FORMYL NUCLEIC ACID" (JAPANESE INVENTORS)
Feb 27, 2012; GENEVA, Feb. 27 -- Publication No. WO/2012/023572 was published on Feb. 23. Title of the invention: "PROCESS FOR PRODUCTION OF...