Ferde's father died in 1899 and Elsa took Ferde abroad to study piano, viola and composition in Leipzig, Germany. Given such a musical background, it is perhaps understandable that Ferde became proficient over a remarkable range of instruments including piano (his favored instrument), violin, viola (he became a violist in the LA Symphony), baritone horn, alto horn and cornet.
This command of musical instruments and composition gave Ferde the foundation to later become first an arranger of other composers' music and then an orchestrator of his own compositions.
Grofé left home at the age of 14 and variously worked as a milkman, truck driver, usher, newsboy, elevator operator, helper in a book bindery, iron factory worker, and as a piano player in a bar for two dollars a night and as an accompanist. He continued studying piano and violin. When he was 15 he was performing with dance bands. He also played the alto horn in brass bands. He was 17 when he wrote his first commissioned work.
Grofé's most memorable arrangement is that of George Gershwin's Rhapsody in Blue, which established Grofé's reputation among jazz musicians. Grofé took what Gershwin had written for two pianos and orchestrated it for Whiteman's jazz orchestra. He transformed Gershwin's musical canvas with the colors and many of the creative touches for which it is so well known. He went on to create two more arrangements of the piece in later years. Grofé's 1942 orchestration for full orchestra of Rhapsody in Blue is the one most frequently heard today.
Due to Grofé's ubiquity in arranging large-scale musical works and a perceived paucity of American achievements in serious music, the German conductor Wilhelm Furtwängler complained that "America has no composers, only arrangers."
During this time, Grofé also recorded piano rolls for the Ampico company in New York. These were embellished with extra notes after the recording took place to attempt to convey the thick lush nature of his orchestra's style, and are marked "Played by Ferde Grofé (assisted)".
Grofé was later employed as a conductor and faculty member at the Juilliard School of Music where he taught orchestration.
Today, Grofé remains most famous for his Grand Canyon Suite (1931) a work regarded highly enough to be recorded for RCA Victor with mastery by Arturo Toscanini and the NBC Symphony (in Carnegie Hall in 1945, with the composer present). The earlier Mississippi Suite is also occasionally performed and recorded. Grofé conducted the Grand Canyon Suite and his piano concerto (with pianist Jesús Maria Sanromá) for Everest Records in 1960.
He also composed original film music, including the scores to Minstrel Man (1944), Time Out of Mind (1947), Rocketship X-M (1950) and The Return of Jesse James (1950).
Ferde Grofé died in Santa Monica, California at the age of 80. He was buried in the Mausoleum of the Golden West at the Inglewood Park Cemetery in Inglewood, California.
His soundtrack to the 1950 science fiction film Rocketship X-M included the use of the theremin. His monumental Grand Canyon Suite is his best known work, a masterpiece in orchestration and evocation of mood and location.