Suppression of the activity of an enzyme by a product of the sequence of reactions in which the enzyme is participating. When the product accumulates in a cell beyond an optimal amount, it decreases its own production by inhibiting an enzyme involved in its synthesis. After the product has been used or broken down, inhibition is relaxed and formation of the product resumes. Enzymes whose ability to catalyze a reaction depends on molecules other than the substances on which they act directly are said to be under allosteric control.
Learn more about feedback inhibition with a free trial on Britannica.com.
Feedback is a circular causal process whereby some proportion of a system's output is returned (fed back) to the input. This is often used to control the dynamic behavior of the system. Examples of feedback can be found in most complex systems, such as engineering, architecture, economics, thermodynamics, and biology.
In organizations, feedback is a process of sharing observations, concerns and suggestions between persons or divisions of the organization with an intention of improving both personal and organizational performance.
Feedback and regulation are self related. The negative feedback helps to maintain stability in a system in spite of external changes. It is related to homeostasis. Positive feedback amplifies possibilities of divergences (evolution, change of goals); it is the condition to change, evolution, growth; it gives the system the ability to access new points of equilibrium.
For example, in an organism, most positive feedback provide for fast autoexcitation of elements of endocrine and nervous systems (in particular, in stress responses conditions) and play a key role in regulation of morphogenesis, growth, and development of organs, all processes which are in essence a rapid escape from the initial state. Homeostasis is especially visible in the nervous and endocrine systems when considered at organism level.
Types of feedback are:
The terms negative and positive feedback can be used less formally to describe or imply criticism and praise, respectively. This may lead to confusion with the terms positive and negative reinforcement.
Systems which include feedback are prone to hunting, which is oscillation of output resulting from improperly tuned inputs of first positive then negative feedback. Audio feedback typifies this form of oscillation.
Negative feedback was applied by Harold Stephen Black to electrical amplifiers in 1927, but he could not get his idea patented until 1937. Arturo Rosenblueth, a Mexican researcher and physician, co-authored a seminal 1943 paper Behavior, Purpose and Teleology that, according to Norbert Wiener (another co-author of the paper), set the basis for the new science of cybernetics. Rosenblueth proposed that behavior controlled by negative feedback, whether in animal, human or machine, was a determinative, directive principle in nature and human creations.. This kind of feedback is studied in cybernetics and control theory.
Feedback is present in many natural and human systems. Feedback is usually bipolar—that is, positive and negative—in natural environments, which, in their diversity, furnish synergic and antagonistic responses to the output of any system.
Biological systems contain many types of regulatory circuits, both positive and negative. As in other contexts, positive and negative don't imply consequences of the feedback have good or bad final effect. A negative feedback loop is one that tends to slow down a process, while the positive feedback loop tends to accelerate it. The mirror neurons are part of a social feedback system, when an observed action is ´mirrored´ by the brain - like a self performed action.
Feedback is also central to the operations of genes and gene regulatory networks. Repressor (see Lac repressor) and activator proteins are used to create genetic operons, which were identified by Francois Jacob and Jacques Monod in 1961 as feedback loops. These feedback loops may be positive (as in the case of the coupling between a sugar molecule and the proteins that import sugar into a bacterial cell), or negative (as is often the case in metabolic consumption).
Any self-regulating natural process involves feedback and is prone to hunting. A well known example in ecology is the oscillation of the population of snowshoe hares due to predation from lynxes.
In zymology, feedback serves as regulation of activity of an enzyme by its direct product(s) or downstream metabolite(s) in the metabolic pathway (see Allosteric regulation).
Hypothalamo-pituitary-adrenal and ovaraian or testicular axis is largely controlled by positive and negative feedback, much of which is still unknown.
The climate system is characterized by strong feedback loops between processes that affect the state of the atmosphere, ocean, and land. A simple example is the ice-albedo positive feedback loop whereby melting snow exposes more dark ground (of lower albedo), which in turn absorbs heat and causes more snow to melt.
The most common general-purpose controller using a control-loop feedback mechanism is a proportional-integral-derivative (PID) controller. Each term of the PID controller copes with time. The proportional term handles the present state of the system, the integral term handles its past, and the derivative or slope term tries to predict and handle the future.
George Soros used the word "reflexivity" to describe feedback in the financial markets and developed an investment theory based on this principle.
The conventional economic equilibrium model of supply and demand supports only ideal linear negative feedback and was heavily criticized by Paul Ormerod in his book "The Death of Economics" which in turn was criticized by traditional economists. This book was part of a change of perspective as economists started to recognise that Chaos Theory applied to nonlinear feedback systems including financial markets.In the World System development The hyperbolic growth of the world population observed till the 1970s has recently been correlated to a non-linear second order positive feedback between the demographic growth and technological development that can be spelled out as follows: technological growth - increase in the carrying capacity of land for people - demographic growth - more people - more potential inventors - acceleration of technological growth - accelerating growth of the carrying capacity - the faster population growth - accelerating growth of the number of potential inventors - faster technological growth - hence, the faster growth of the Earth's carrying capacity for people, and so on.
Confirmation |
Your answer was incorrect. |
Corrective |
Your answer was incorrect. The correct answer was Jefferson. |
Explanatory |
Your answer was incorrect because Carter was from Georgia; only Jefferson called Virginia home. |
Diagnostic |
Your answer was incorrect. Your choice of Carter suggests some extra instruction on the home states of past presidents might be helpful. |
Elaborative |
Your answer, Jefferson, was correct. The University of Virginia, a campus rich with Jeffersonian architecture and writings, is sometimes referred to as Thomas Jefferson’s school. |
A different application of feedback in education is the system for "continuous improvement" of engineering curricula monitored by the Accreditation Board for Engineering and Technology (ABET)
If the signal is inverted on its way round the control loop, the system is said to have negative feedback; otherwise, the feedback is said to be positive. Negative feedback is often deliberately introduced to increase the stability and accuracy of a system. This scheme can fail if the input changes faster than the system can respond to it. When this happens, the lag in arrival of the feedback signal results in positive feedback, causing the output to oscillate or hunt Positive feedback is usually an unwanted consequence of system behaviour.
Harry Nyquist contributed the Nyquist plot for assessing the stability of feedback systems. An easier assessment, but less general, is based upon gain margin and phase margin using Bode plots (contributed by Hendrik Bode). Design to insure stability often involves frequency compensation, one method of compensation being pole splitting.
In audio systems, feedback is a high-pitched squeal that occurs when the speaker and microphone are in phase. Rotating one of the two 180 degrees electrically out of phase will eliminate the problem.
The windmill was enhanced in 1745 by blacksmith Edmund Lee who added a fantail to keep the face of the windmill pointing into the wind. In 1787 Thomas Mead regulated the speed of rotation of a windmill by using a centrifugal pendulum to adjust the distance between the bedstone and the runner stone (i.e. to adjust the load).
The use of the centrifugal governor by James Watt in 1788 to regulate the speed of his steam engine was one factor leading to the Industrial Revolution. Steam engines also use float valves and pressure release valves as mechanical regulation devices. A mathematical analysis of Watt's governor was done by James Clerk Maxwell in 1868.
The Great Eastern was one of the largest steamships of its time and employed a steam powered rudder with feedback mechanism designed in 1866 by J.McFarlane Gray. Joseph Farcot coined the word servo in 1873 to describe steam powered steering systems. Hydraulic servos were later used to position guns. Elmer Ambrose Sperry of the Sperry Corporation designed the first autopilot in 1912. Nicolas Minorsky published a theoretical analysis of automatic ship steering in 1922 and described the PID controller.
Internal combustion engines of the late 20th century employed mechanical feedback mechanisms such as vacuum advance (see: Ignition timing) but mechanical feedback was replaced by electronic engine management systems once small, robust and powerful single-chip microcontrollers became affordable.
Examples of feedback in organizations: