fatty kidney

(R)-2-hydroxy-fatty-acid dehydrogenase

In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase is an enzyme that catalyzes the chemical reaction

(R)-2-hydroxystearate + NAD+ rightleftharpoons 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (R)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+. This reaction is important in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.


  • Levis GM "2-Hydroxy fatty acid oxidases of rat kidney". Biochem. Biophys. Res. Commun. 38 470–7.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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