Voiced by Kyla Pratt, the 14-year-old protagonist is usually embarrassed by the way her parents act. She enjoys hanging out with her friends, even though they have gotten her into trouble, and left her to face danger by herself many times. She listens to and respects her parents, but often caves in to peer pressure. She is also somewhat of a feminist at times, and is very logical.
Voiced by Tommy Davidson, Penny's over-protective father who some may call a born loser; he is the longtime rival of mogul Wizard Kelly, and is the owner of Proud Snacks (which makes anybody who eats them sick except Peabo, who is the only person who likes them). Oscar Proud is unique in that he of all the other characters in the show exhibits the most overt signs of being a Toon; hisbody responds to over-the-top physical reactions by squishing flat as a pancake, burning into a puff of ashes, stretching thin as a rubber band, glowing x-ray skeleton style, etc. Penny shows early signs of this as well, and Suga Mama repeatedly makes references to Penny "taking after her daddy". One of the main parts of Oscar's personality is that he is attracted to gorgeous women even though he is married. He has never actually cheated on his wife, but he does flirt with other women, even when he knows Trudy is watching.
Voiced by Paula Jai Parker, Penny's ambitious, loving and rational mother is respectful of others and works as a veterinarian. Since she makes more money than Oscar, she asserts dominance over him at times. She gets very annoyed when she catches Oscar flirting with other women.
Voiced by Tara Strong, Penny's trouble-making 1-year-old twin little siblings often torture Sugar Mama's pet poodle. BeBe's a boy with a huge afro and always has a bottle in his mouth, while Cece's a girl with brown hair and a pink dress with pigtails.
Voiced by Jo Marie Payton, Penny's hip, wrestling-loving grandma who does Tae-bo. She is very sassy, and always gets straight to the point when she talks. She constantly insults, discourages and beats up Oscar, but she loves him deep down. Her age is unknown, and often made fun of by her son. An event from twenty years ago shows her looking exactly the same as before, an indication that she could be very well over ninety. Suga Mama is in love with Papi.
Voiced by Karen Malina White, Penny's somewhat eccentric and fat friend is heartfelt and a backstabber but hilarious & honest; she has yellow hair and is in love with Sticky Webb. Dijonay is loud and she's always getting Penny into trouble. She's very similar to Kim Parker (The Parkers) in appearance and personality. She is also the cheerleading captain at her school.
Voiced by Orlando Brown, Penny's friend and Dijonay's love interest, though he dislikes her rather strong come-ons. Though he does have feelings for her, he only let those show once in one episode. He is very intelligent and knows a lot about computers. Sticky's still upset because his parents got a divorce.
Voiced by Soleil Moon Frye, Penny's nerdy friend. Zoey has red hair, braces, and freckles. She usually shows low self esteem at times, and always tries to show others that she's not all nerd. Zoey loves animals and has a scratchy voice. Zoey's aunt is a lawyer and her mom's a limo driver.
Voiced by Alisa Reyes, Penny's on again/off again friend. She's Hispanic and is extremely rude to Penny (but makes sure the adults don't know that). She is also a cheerleader at Penny's school and is one of the most popular girls there. There is no reference to it within the show itself, but Lacienega and her mother Sunset share their names with actual streets in Los Angeles, California. Deep down Lacienega's jealous because Dijonay would rather hang out with Penny than her and Lacienega doesn't like to share Dijonay with Penny. Lacienega's also insecure due to having big feet.
Voiced by Phil LaMarr, Penny's effeminate male friend, and is a good fashion designer and basketball player. He's also a choreographer. In public he's forced to call his father "Coach" instead of "Daddy", an indicator that Michael may also be homosexual.. Michael's dad is the coach at Willy T. Ribs Middle School.
Voiced by Carlos Mencia, and Maria Canals Barrera. Oscar & Trudy's friends, whose father Papi is the somewhat-unwilling boyfriend to Suga Mama, and whose daughter Lacienega is the even-more unwilling friend to Penny. When they first moved to the neighborhood, Oscar made a comment about Sunset's sexy physique, and was attracted to her for a little bit, until Felix's TV caught his attention. The name Felix, together with Oscar Proud, makes reference to the Odd Couple of Felix Unger and Oscar Madison; Sunset, and her daughter Lacienega, both share their names with actual streets in Los Angeles CA.
Voiced by Alvaro Guttieriez, Felix's father, Lacienega's grandfather, and the elderly "boyfriend" of Suga Mama, who mistook him for Ceaser Romero due to his dressing like The Joker from Batman. He constantly makes jokes about Suga Mama in Spanish and then laughs at the top of his lungs; his accent titillates Suga Mama, although whether she understands the context of his words or not is unclear. He lives with his son Felix, which in one episode, annoys Sunset.
Voiced by Aries Spears, Oscar Proud's successful & life-long rival who made his fortune on a basketball shot that Oscar missed back in high-school; he now owns nearly everything (or so it seems). It is implied that Wizard Kelly is a pun for Magic Johnson and R.Kelly. The name of the town that the Proud Family lives in is Wizville CA, which is shown when Penny gets her drivers license in The Proud Family Movie. A running gag of the series is that he doesn't remember the names of the main characters (although he interacts with them enough to actually "know" them), no matter how many times they tell him, (eg: he always calls Zoey "Susie" & Oscar Oliver Prune). Wizard Kelly's face is never shown in any of the episodes. In the Proud Family Movie a single shot of his full face can be seen. Instead, the shot is awkwardly angled so that he can only be seen from the top of the mouth down. It was planned to introduce his sexy younger sister to the show as a recurring character who is a love interest for Oscar and causes a conflict in Oscar and Trudy's marriage, but she was dropped when Disney Channel decided to pull the show's plug.
Voiced by Cree Summer, an annoying 7 year old who always makes trouble for Oscar, he also as a crush on Penny. Despite his age he is very smart. He is also constantly telling Oscar he doesn't think he should do something but despite his warnings, Oscar does it anyway and gets hurt. Usually ending with: "I told you, Mr. Proud". He is also the only person who likes Proud Snacks.
They are three girls constantly mugging people for money and show violent tendencies. In the multi-cultural episode it is revealed that their parents make them work... a lot. It is also revealed that their mother is Jamaican. She wears flower print clothes that are orange (everyone else is entirely blue including their clothes). She is also blue and wears her hair in dreadlocks with a barrette. Both parents are very fat. It is mentioned in some of the episodes that the girls are 'ashy', thus the blue tone. Nubia is the middle child and the leader of the pack, considering she does most (preferably 'all') of the talking. Gina is the oldest, despite being the smallest and the collector of the money her sisters mug; as a habit, she always has her hand out. In the episode, "Makeover", Olei (the 'muscle' of the group) is separated from the other 2 sisters. It is revealed that she isn't actually as fat as she is shown, her overalls are just baggy, she is slightly chubby. Olei is the youngest of the 3 sisters even though she is the biggest. The Gross Sisters' parents always force them to work on the weekends and that's why they're bullies.
One brother and two sisters of an Asian family, who are straight-A students, usually trying to live up to their father's expectations. They really enjoy academic challenges and showing people up for having talents in other subjects. They even study karate with their uncle.
He could be described as a running gag, but he's a little too frequent. He runs as Oscar's "occasional rival" usually challenging him to bets or just making trouble. Being so smart, he constantly mocks Oscar's lower intelligence, particularly for the fact that Oscar is an adult. No one else can tell that he can talk it seems, but Oscar. (As the name implies- he has a red/ pink nose).
Voiced by Cedric The Entertainer, Oscar's older brother & Sugar Mama's favorite son. He is a fan of blues like Hall & Oates & others. He sings & talks like the lead singer of the '70's band The Commodores.
The doctor Trudy calls when Oscar or someone else in the family gets hurt or needs something from the doctor. He is voiced by Mr. T. All his house calls are expensive, especially Oscar's. He also seems to use very violant methods when treating Oscar, that no one else seems to ever have gotten. Unlike Oscar however, he treats Suga Moma in great respect.
Omar first appears in "Rumors" as the school quarterback Penny and most other girls in the school have a crush on. Omar appears to be dimwitted but is a good quarterback. Omar is mostly seen with Frankie, Sticky, and Duke mocking Penny and her friends
Frankie first made his appearance in "she's got game" when he mocks Penny because she's a girl trying to play football. Frankie appears to have a crush on Penny, because on every episode he's appeared in, he's mean to Penny in the beginning, but nice to her towards the end.
Penny's surfer friend. Duke originally came to the show as a flat character, but later grew into a bigger roll as the show progressed