Transcription Factor II D

Transcription Factor II D (TF_IID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TF_IID is itself composed of several subunits called TBP-associated factors (TAFs, of which there are 14) and the TATA Binding Protein (TBP).

In a test tube, only TBP is necessary for transcription at promoters that contain a TATA box. TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to.

Subunits in the TFIID complex include:

• TBP (TATA binding protein)
• TAF1 (TAFII250)
• TAF2 (CIF150)
• TAF4 (TAFII130/135)
• TAF4B (TAFII105)
• TAF5 (TAFII100)
• TAF6 (TAFII70/80)
• TAF7 (TAFII55)
• TAF9 (TAFII31/32)
• TAF10 (TAFII30)
• TAF11 (TAFII28)
• TAF12 (TAFII20/15)
• TAF13 (TAFII18)
• TAF15 (TAFII68)

See also

• Transcription (genetics)
• Eukaryotic transcription

References

External links