extravascular fluid


Transudate is extravascular fluid with low protein content and a specific gravity <1.012. It has low nucleated cell counts (less than 500 to 1000 /microlit) and the primary cell types are mononuclear cells: macrophages, lymphocytes and mesothelia cells. For instance, an ultrafiltrate of blood plasma is transudate. It results from increased fluid pressures or diminished osmotic forces in the plasma.

In females, transudation is a method of lubrication during sexual arousal.

Transudate vs. exudate

Levels of lactate dehydrogenase (LDH) can be used to distinguish transudate from exudate.

Transudate usually appears more clear than exudate.


The most common causes of pathologic transudate include embolism, left ventricular heart failure, and cirrhosis. (Cirrhosis leads to hypoalbuminaemia and decreasing of osmotic pressure that causes edema.)


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