Condition in which a fertilized egg is imbedded outside the uterus (see fertilization). Early on, it may resemble a normal pregnancy, with hormonal changes, amenorrhea, and development of a placenta. Later, most patients have pain as the growing embryo stretches the structure it is attached to. Rupture may cause life-threatening bleeding. A tubal pregnancy may result from obstruction of the egg's passage through the fallopian tube. In an ovarian pregnancy, the egg is fertilized before it leaves the ovary. Implantation elsewhere in the abdomen is an abdominal pregnancy.
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A fetus (or foetus or fœtus) is a developing mammal or other viviparous vertebrate, after the embryonic stage and before birth. The plural is fetuses, or sometimes feti. The fetal stage of prenatal development starts when the major structures have formed, and lasts until birth.
Fœtus is an English variation on the Latin spelling, and has been in use since at least 1594, according to the Oxford English Dictionary, which describes "fœtus" as "incorrectly written". The variant fœtus may have originated with an error by Saint Isidore of Seville, in AD 620. The preferred spelling in the United States is fetus, but the variants foetus and fœtus persist in other English-speaking countries and in some medical contexts, as well as in some other languages (e.g., French). In technical usage, fetus is now the standard spelling throughout the English-speaking world.
Fetuses are not capable of feeling pain at the beginning of the fetal stage, and will not be able to feel pain until the third trimester. At this point in development, uncontrolled movements and twitches occur as muscles, the brain and pathways begin to develop.
From weeks 11 to 14, the fetal eyelids close and remain closed for several months, and the fetus' sex may be apparent. Tooth buds appear, the limbs are long and thin, and red blood cells are produced in the liver, however the majority of red blood cells will be made later in gestation (at 21 weeks) by bone marrow. A fine hair called lanugo develops on the head. The gastrointestinal tract, still forming, starts to collect sloughed skin and lanugo, as well as hepatic products, forming meconium (stool). Fetal skin is almost transparent. The first measurable signs of EEG movement occur in the 12th week.
Maternal factors include maternal weight, body mass index, nutritional state, emotional stress, toxin exposure (including tobacco, alcohol, heroin, and other drugs which can also harm the fetus in other ways), and uterine blood flow.
Placental factors include size, microstructure (densities and architecture), umbilical blood flow, transporters and binding proteins, nutrient utilization and nutrient production.
Fetal factors include the fetus genome, nutrient production, and hormone output. Also, female fetuses tend to weigh less than males, at full term.
Fetal growth is often classified as follows: small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). SGA can result in low birth weight, although premature birth can also result in low birth weight. Low birth weight increases risk for perinatal mortality (death shortly after birth), asphyxia, hypothermia, polycythemia, hypocalcemia, immune dysfunction, neurologic abnormalities, and other long-term health problems. SGA may be associated with growth delay, or it may instead be associated with absolute stunting of growth.
Viability is defined as the ability of fetuses to survive in the extrauterine environment... There is no sharp limit of development, age, or weight at which a fetus automatically becomes viable or beyond which survival is assured, but experience has shown that it is rare for a baby to survive whose weight is less than 500 gm or whose fertilization age is less than 22 weeks. Even fetuses born between 26 and 28 weeks have difficulty surviving, mainly because the respiratory system and the central nervous system are not completely differentiated... If given expert postnatal care, some fetuses weighing less than 500 gm may survive; they are referred to as extremely low birth weight or immature infants.... Prematurity is one of the most common causes of morbidity and prenatal death.
During the past several decades, neonatal care has improved with advances in medical science, and therefore the point of viability may have moved earlier. As of 2006, the two youngest children to survive premature birth are thought to be James Elgin Gill (born on 20 May 1987 in Ottawa, Canada, at 21 weeks and 5 days gestational age), and Amillia Taylor (born on 24 October 2006 in Miami, Florida, at 21 weeks and 6 days gestational age). Both children were born just under 20 weeks from fertilization, or a few days past the midpoint of an average full-term pregnancy. Despite their premature births, both developed into healthy children.
Whether a fetus has the ability to feel pain and to suffer is part of the abortion debate. For example, in the USA legislation has been proposed by pro-life advocates requiring abortion providers to tell a woman that the fetus may feel pain during the abortion procedure, and that require her to accept or decline anesthesia for the fetus.
Quickening is the first maternally discernible fetal movement, which is often felt around the middle of pregnancy. Women who have already given birth have more relaxed uterine muscles that are consequently more sensitive to fetal motion, and for them fetal motion may be felt as early as 18 weeks. Mothers can begin to feel quickening anywhere between 18 and 24 weeks of gestation.
The parts of the fetal brain that control movement will not fully form until late in the second trimester, and the first part of the third trimester. Control of movement is limited at birth, and purposeful voluntary movements develop in the first year after birth. However, locomotor activity begins during the late embryonic stage, and changes in nature throughout development. Muscles begin to move as soon as they are innervated. These first movements are not reflexive, but arise from nerve impulses originating in the spinal cord. As the nervous system matures, muscles can move in response to stimuli, though this is not a voluntary movement.
The circulatory system of a human fetus works differently from that of born humans, mainly because the lungs are not in use: the fetus obtains oxygen and nutrients from the mother through the placenta and the umbilical cord.
With the first breath after birth, the system changes suddenly. The pulmonary resistance is dramatically reduced ("pulmo" is from the Latin for "lung"). More blood moves from the right atrium to the right ventricle and into the pulmonary arteries, and less flows through the foramen ovale to the left atrium. The blood from the lungs travels through the pulmonary veins to the left atrium, increasing the pressure there. The decreased right atrial pressure and the increased left atrial pressure pushes the septum primum against the septum secundum, closing the foramen ovale, which now becomes the fossa ovalis. This completes the separation of the circulatory system into two halves, the left and the right.
The ductus arteriosus normally closes off within one or two days of birth, leaving behind the ligamentum arteriosum. The umbilical vein and the ductus venosus closes off within two to five days after birth, leaving behind the ligamentum teres and the ligamentum venosus of the liver respectively.
Blood from the placenta is carried to the fetus by the umbilical vein. About half of this enters the fetal ductus venosus and is carried to the inferior vena cava, while the other half enters the liver proper from the inferior border of the liver. The branch of the umbilical vein that supplies the right lobe of the liver first joins with the portal vein. The blood then moves to the right atrium of the heart. In the fetus, there is an opening between the right and left atrium (the foramen ovale), and most of the blood flows through this hole directly into the left atrium from the right atrium, thus bypassing pulmonary circulation. The continuation of this blood flow is into the left ventricle, and from there it is pumped through the aorta into the body. Some of the blood moves from the aorta through the internal iliac arteries to the umbilical arteries, and re-enters the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the woman's circulation.
Some of the blood entering the right atrium does not pass directly to the left atrium through the foramen ovale, but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a special connection between the pulmonary artery and the aorta, called the ductus arteriosus, which directs most of this blood away from the lungs (which aren't being used for respiration at this point as the fetus is suspended in amniotic fluid).
|foramen ovale||fossa ovalis|
|ductus arteriosus||ligamentum arteriosum|
|extra-hepatic portion of the fetal left umbilical vein||ligamentum teres hepatis (the "round ligament of the liver").|
|intra-hepatic portion of the fetal left umbilical vein (the ductus venosus)||ligamentum venosum|
|proximal portions of the fetal left and right umbilical arteries||umbilical branches of the internal iliac arteries|
|distal portions of the fetal left and right umbilical arteries||medial umbilical ligaments (urachus)|
In addition to differences in circulation, the developing fetus also employs a different type of oxygen transport molecule than adults (adults use adult hemoglobin). Fetal hemoglobin enhances the fetus' ability to draw oxygen from the placenta. Its association curve to oxygen is shifted to the left, meaning that it will take up oxygen at a lower concentration than adult hemoglobin will. This enables fetal hemoglobin to absorb oxygen from adult hemoglobin in the placenta, which has a lower pressure of oxygen than at the lungs.
Congenital anomalies are anomalies that are acquired before birth. Infants with certain congenital anomalies of the heart can survive only as long as the ductus remains open: in such cases the closure of the ductus can be delayed by the administration of prostaglandins to permit sufficient time for the surgical correction of the anomalies. Conversely, in cases of patent ductus arteriosus, where the ductus does not properly close, drugs that inhibit prostaglandin synthesis can be used to encourage its closure, so that surgery can be avoided.
A developing fetus is highly susceptible to anomalies in its growth and metabolism, increasing the risk of birth defects. One area of concern is the pregnant woman's lifestyle choices made during pregnancy Diet is especially important in the early stages of development. Studies show that supplementation of the woman's diet with folic acid reduces the risk of spina bifida and other neural tube defects. Another dietary concern is whether the woman eats breakfast. Skipping breakfast could lead to extended periods of lower than normal nutrients in the woman's blood, leading to a higher risk of prematurity, or other birth defects in the fetus. During this time alcohol consumption may increase the risk of the development of Fetal alcohol syndrome, a condition leading to mental retardation in some infants. Smoking during pregnancy may also lead to reduced birth weight. Low birth weight is defined as 2500 grams (5.5 lb). Low birth weight is a concern for medical providers due to the tendency of these infants, described as premature by weight, to have a higher risk of secondary medical problems.
In the United States, some states have laws that impose strict punishments for those who inflict violence that results in damage to a fetus or the unwanted termination of a pregnancy. The severity of the punishment, and the stage of fetal development where laws start to apply vary from state to state.
Abortion of a fetus is legal in many countries such as Australia, Canada, Mexico, UK and USA. Many of those countries that allow abortion during the fetal stage have gestational time limits, so that late-term abortions are not normally allowed.
The fetus of most mammals develops similarly to the Homo sapiens fetus. After the first stages of development, the human embryo reaches a stage very similar to all other vertebrates. The anatomy of the area surrounding a fetus is different in litter-bearing animals compared to humans: each fetus is surrounded by placental tissue and is lodged along one of two long uteri instead of the single uterus found in a human female. Development at birth is similar, with animals also having a poorly developed sense of vision and other senses.
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