An epoxide is a cyclic ether containing an oxygen atom attached to two adjacent carbon atoms of a hydrocarbon. Epoxides have greater reactivity than typical ethers. An example is ethylene oxide that acts as a fumigant and makes antifreeze. Industrial epoxides involve converting an alkene to a chlorohydrin, then treating the chlorohydrin with a base to get rid of hydrochloric acid. Acid or base conditions allow epoxides to form a variety of products such as propylene glycol. Epoxides can also assemble polymers such as epoxies, used as powerful adhesives. Epoxy resin comes from the reaction of epichlorohydrin with bisphenol A.
Ring strain causes epoxides' ease of reactivity. When nucleophiles attack the electrophilic carbon atom of the C-O bond, the bond breaks, the ring opens and relieves the ring strain. As a result, 2 alcohols get produced.
EPOXIDE MIGRATION AND PSEUDO-EPOXIDE MIGRATION OF 1,6:2,3- AND 1,6:3,4-DIANHYDRO-[beta]-D-HEXOPYRANOSES. SYNTHESIS OF SOME DEOXY HALO DERIVATIVES OF 1,6-ANHYDRO-[beta]-D-HEXOPYRANOSES
Oct 01, 2006; epoxide or pseudo-epoxide migration of 1,6:2,3-dianhydro- and 1,6:3,4-dianhydro-β-D-hexopyranoses was effected by...
Patent Issued for Soluble Epoxide Hydrolase Inhibitors, Compositions Containing Such Compounds and Methods of Treatment
Jun 19, 2013; A patent by the inventors Colletti, Steven L. (Princeton Junction, NJ); Shen, Hong (West Windsor, NJ); Ding, Fa-Xiang (Staten...