Duke Georg was a member of the Order of the Golden Fleece.
George, as the eldest son, received an excellent training in theology and other branches of learning, and was thus much better educated than most of the princes of his day.
As early as 1488, when his father was in Friesland fighting on behalf of the emperor, George was regent of the ducal possessions, which included the Margraviate of Meissen with the cities of Dresden and Leipzig.
George was married at Dresden, on 21 November, 1496, to Barbara of Poland, daughter of Casimir IV, King of Poland and Elisabeth, daughter of Albrecht II of Hungary. They had ten children, but all, with the exception of a daughter, died before their father:
In 1498, the emperor granted Albert the Brave the hereditary governorship of Friesland. At Maastricht, 14 February, 1499, Albert settled the succession to his possessions, and endeavoured by this arrangement to prevent further partition of his domain. He died 12 September 1500, and was succeeded in his German territories by George as the head of the Albertine line, while George's brother Heinrich became hereditary governor of Friesland.
The Saxon occupation of Friesland, however, was by no means secure and was the source of constant revolts in that province. Consequently Heinrich, who was of a rather inert disposition, relinquished his claims to the governorship, and in 1505 an agreement was made between the brothers by which Friesland was transferred to George, while Heinrich received an annuity and the districts of Freiberg and Wolkenstein. But this arrangement did not restore peace in Friesland, which continued to be an unceasing source of trouble to Saxony, until finally the duke was obliged, in 1515, to sell it to Burgundy for the very moderate price of 100,000 florins. These troubles outside of his Saxon possessions did not prevent George from bestowing much care on the government of the ducal territory proper. When regent, during the lifetime of his father, the difficulties arising from conflicting interests and the large demands on his powers had often brought the young prince to the verge of despair.
In a short time, however, he developed decided ability as a ruler; on entering upon his inheritance he divided the duchy into governmental districts, took measures to suppress the robber-knights, and regulated the judicial system by defining and readjusting the jurisdiction of the various law courts. In his desire to achieve good order, severity, and the amelioration of the condition of the people, he sometimes ventured to infringe even on the rights of the cities. His court was better regulated than that of any other German prince, and he bestowed a paternal care on the University of Leipzig, where a number of reforms were introduced, and Humanism, as opposed to Scholasticism, was encouraged.
The duke was not blind to the undeniable abuses existing at that time in the Church. In 1519, despite the opposition of the theological faculty of the university, he originated the Disputation of Leipzig, with the idea of helping forward the cause of truth, and was present at all the discussions. In 1521, at the Diet of Worms, when the German princes handed in a paper containing a list of "grievances" concerning the condition of the Church, George added for himself twelve specific complaints referring mainly to the abuse of Indulgences and the annates.
In 1525 he combined with his Lutheran son-in-law, Landgrave Philip of Hesse, and his cousin, the Elector Frederick the Wise, to suppress the revolt of the peasants, who were defeated near Frankenhausen in Thuringia. Some years later, he wrote a forcible preface to a translation of the New Testament issued at his command by his private secretary, Hieronymus Emser, as an offset to Luther's version. Lutheran books were confiscated by his order, wherever found, though he refunded the cost of the books. He proved himself in every way a vigorous opponent of the Lutherans, decreeing that Christian burial was to be refused to apostates, and recreant ecclesiastics were to be delivered to the bishop of Merseburg.
For those, however, who merely held anti-catholic opinions, the punishment was only expulsion from the duchy. The duke deeply regretted the constant postponement of the ardently desired council, from the action of which so much was expected. While awaiting its convocation, he thought to remove the more serious defects by a reform of the monasteries, which had become exceedingly worldly in spirit and from which many of the inmates were departing. He vainly sought to obtain from the Curia the right, which was sometimes granted by Rome, to make official visitations to the conventual institutions of his realm. His reforms were confined mainly to uniting the almost vacant monasteries and to matters of economic management, the control of the property being entrusted in most cases to the secular authorities.
In 1525, Duke George formed, with some other German rulers, the League of Dessau, for the protection of Catholic interests. In the same way he was the animating spirit of the League of Halle, formed in 1533, from which sprang in 1538 the Holy League of Nuremberg for the maintenance of the religious Peace of Nuremberg.
The vigorous activity displayed by the duke in so many directions was not attended with much success. Most of his political measures, indeed, stood the test of experience, but in ecclesiastico-political matters he witnessed with sorrow the gradual decline of Catholicism and the spread of Lutheranism within his dominions, in spite of his earnest efforts and forcible prohibition of the new doctrine. Furthermore, during George's lifetime his nearest relations his son-in-law Philip of Hesse, and his brother Heinrich, joined the Reformers.
He spent the last years of his reign in endeavours to secure a Catholic successor, thinking by this step to check the dissemination of Lutheran opinions. The only one of George's sons then living was the weak-minded and unmarried Frederick. The intention of his father was that Frederick should rule with the aid of a council. Early in 1539, Frederick was married to Elizabeth of Mansfeld, but he died shortly afterwards, leaving no prospect of an heir. According to the act of settlement of 1499, George's Protestant brother Heinrich was now heir prospective; but George, disregarding his father's will, sought to disinherit his brother and to bequeath the duchy to Ferdinand, brother of Charles V. His sudden death prevented the carrying out of this intention.