Ecgonine is an organic chemical and tropane alkaloid found naturally in coca leaves. It is has a close structural relation to cocaine: it is both a metabolite and a Precursor, and as such, it is a controlled substance, as are all known substances which can be used as precursors to ecgonine itself.
Structurally, ecgonine is a cycloheptane derivative with a nitrogen bridge. It is obtained by hydrolysis of cocaine with acids or alkalis, and crystallizes with one molecule of water, the crystals melting at 198–199°C. It is levorotary, and on warming with alkalis gives iso-ecgonine, which is dextrorotary.
It is a tertiary base, and has the properties of an acid and an alcohol. It is the carboxylic acid corresponding to tropine, for it yields the same products on oxidation, and by treatment with phosphorus pentachloride is converted into anhydroecgonine, C9H13NO2, which, when heated to 280°C with hydrochloric acid, eliminates carbon dioxide and yields tropidine, C8H13N.
Studies in the area of analytical and bioanalytical chemistry reported from University of Santiago of Compostela, Institute of Legal Medicine.(Report)
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Sensitivity and specificity of the Cozart Microplate EIA Cocaine Oral Fluid at proposed screening and confirmation cutoffs
Sep 01, 2003; Background: Oral fluid is currently being evaluated as an alternative matrix for monitoring illicit drugs in federally mandated...