Diego Luna hosted the awards alone for the first time. He previously co-hosted the 2002 edition.

Nominations

Artist of the Year

• Café Tacuba
• Juanes
• La Ley
• Maná
• Molotov
• Natalia Lafourcade

Video of the Year

• Café Tacuba — "EO (El Sonidero)" (Directed by Arni and Kinski)
• Gustavo Cerati — "Cosas Imposibles" (Directed by Diego Kaplan and Juan Antin)
• Juanes — "Fotografía (Feat. Nelly Furtado)" (Directed by Picky Talarico)
• La Ley — "Ámate y Sálvate" (Directed by Gustavo Garzón)
• Molotov — "Frijolero" (Directed by Paul Beck and Jason Archer)

Best Solo Artist

• Diego Torres
• Gustavo Cerati
• Juanes
• Natalia Lafourcade
• Ricky Martin

Best Group or Duet

• Babasónicos
• Catupecu Machu
• La Oreja de Van Gogh
• Maná
• Molotov

Best Pop Artist

• Diego Torres
• Natalia Lafourcade
• Paulina Rubio
• Ricky Martin
• Thalía

Best Rock Artist

• Gustavo Cerati
• Jaguares
• Juanes
• La Ley
• Maná

Best Alternative Artist

• Café Tacuba
• El Otro Yo
• Kinky
• Molotov
• Plastilina Mosh

Best Independent Artist

• Hermanos Brothers
• Miranda!
• Panda
• Totus Toss
• Volován

No public voting

Best Pop Artist — International

• Avril Lavigne
• Christina Aguilera
• Justin Timberlake
• Madonna
• Robbie Williams

Best Rock Artist — International

• Audioslave
• Coldplay
• Evanescence
• Linkin Park
• Radiohead

Best New Artist — International

• Audioslave
• Beyoncé
• Evanescence
• t.A.T.u
• The White Stripes

Best Artist — Mexico

• Café Tacuba
• Maná
• Mœnia
• Molotov
• Natalia Lafourcade

Best New Artist — Mexico

• Cartel de Santa
• Inspector
• Natalia Lafourcade
• Panteón Rococó
• Qbo

Best Artist — Central

• Aterciopelados
• Juanes
• La Ley
• Líbido
• Los Prisioneros

Best New Artist — Central

• Coni Lewin
• Marciano
• Pettinellis
• TK
• Zen

Best Artist — Argentina

• Babasónicos
• Bersuit Vergarabat
• Gustavo Cerati
• Kevin Johansen
• Vicentico

Best New Artist — Argentina

• Carajo
• Emme
• Kevin Johansen
• Miranda!
• Vicentico

Awards by Countries

Performances

Pre-show

• Elan — "Midnight"
• Kevin Johansen — "Sur o no Sur"
• Qbo — "No Más"
• Líbido — "Frágil"
• Catupecu Machu — "Y Lo Que Quiero Es Que Pises sin el Suelo"

Main show

• Alex Lora, Andrea Echeverri, Charly Alberti, Jorge González, Juanes, Plastilina Mosh, Ricky Martin and Vicentico as "Los Black Stripes" — "We Are South American Rockers" / "Bolero Falaz" / "Gimme Tha Power" / "Livin' la Vida Loca" / "El Matador"
• Alejandro Sanz — "No Es Lo Mismo"
• Korn — "Right Now"
• La Ley and Ely Guerra — "Ámate y Sálvate" and "El Duelo"
• Dido — "White Flag"
• Café Tacuba — "Eres" and "Cero y Uno"
• The Mars Volta — "Drunkenship of Lanterns"
• Gustavo Cerati — "Artefacto"
• Natalia Lafourcade and Control Machete — "En el 2000" and "Bien, Bien"
• Iggy Pop and Sum 41 — "Little Know It All"

Appearances

• Madonna — introduced the audience to the show
• Britney Spears, Erik Estrada, Daisy Fuentes, Iggy Pop and Sum 41 — appeared in the Opening Sketch
• Diego Maradona — appeared during Diego Luna's opening monologue
• Alex Lora, Juanes and Charly Alberti — presented Best Group or Duet
• Andrea Echeverri and Dido — introduced Alejandro Sanz
• Patricia Velásquez and Sum 41 — presented Best Pop Artist
• Maná (Fher, Alex and Sergio) — presented Best Rock Artist—International
• Daniela Cicarelli, Amelia Vega and Elsa Benítez — presented Best Rock Artist
• Kelly Osbourne and Molotov — introduced Korn
• Catupecu Machu and Leticia Bredice — presented Best New Artist—Argentina
• La Oreja de Van Gogh (Amaia and Pablo) and Mœnia (Alfonso and "Midi") — introduced La Ley
• Elan and María Jimena Pereyra — introduced Dido
• Sofía Mulanovich, Chris Pontius, Steve-O and Manny Puig — presented Best Artist—Central
• Gustavo Cerati — introduced Café Tacuba
• Daisy Fuentes and Deborah Ombres — presented Best Solo Artist
• Zack de la Rocha — introduced The Mars Volta
• The cast of Dirty Sanchez and Fabiola Campomanes — presented Best Alternative Artist
• Natalia Lafourcade and Kinky (Gil and Ulises) — introduced Gustavo Cerati
• Martha Higareda and Alfonso Herrera — introduced Natalia Lafourcade
• Diego Torres, Esther Cañadas and Robi Rosa — presented Video of the Year
• Alejandro Sanz — presented Artist of the Year