Agrippina had nine children by Germanicus, three of whom died young. The six who survived to adulthood were:
Agrippina and Germanicus travelled to the Near East in 19, incurring the displeasure of the emperor Tiberius. Germanicus quarrelled with Gnaeus Calpurnius Piso, the governor of Syria, and died in Antioch in mysterious circumstances. It was widely suspected that Germanicus had been poisoned – perhaps on the orders of Tiberius himself – and Agrippina returned to Rome to avenge his death. She boldly accused Piso of the murder of Germanicus. According to Tacitus (Annals 3.14.1), the prosecution could not prove the poisoning charge, but other charges of treason seemed likely to stick, and Piso committed suicide.
From 19 to 29, Agrippina remained in Rome, becoming increasingly involved with a group of senators who opposed the growing power of Tiberius' favourite Sejanus. Her relations with the emperor became increasingly fraught as she made it clear that she believed that he was responsible for the death of Germanicus. The climate was further poisoned by the "inveterate hatred" that Tiberius' mother felt for her (Tacitus, Annals 4.12), since Agrippina's ambition, to be the mother of emperors and thus Rome's first woman, was an open secret. In 26, the emperor rejected her request that she be allowed to marry again.
Agrippina and her sons Nero and Drusus were arrested in 29 on the orders of Tiberius. They were tried by the Senate and Agrippina was banished to the island of Pandataria (now called Ventotene) in the Tyrrhenian Sea off the coast of Campania where her mother had once been banished. There she was treated with great brutality, losing an eye from the blow of a centurion and later undergoing forcible feeding (Suetonius, Tib.53). She died on 18 October 33 in suspicious circumstances. Her death, according to Suetonius the result of voluntary starvation (ibid), was probably hastened by her realisation that the fall of Sejanus had "led to no abatement of horrors" (Tacitus, Annals 6.25). Tacitus also mentions malnutrition as a likely cause. After her death Tiberius accused her of "having had Asinius Gallus as a paramour and being driven by his death to loathe existence" (Annals 6.25). At Tiberius' prompting the Senate decreed that her birthday should be marked as a day of ill omen (Suet.ibid.).
Drusus died of starvation after being imprisoned in Rome and Nero Caesar either committed suicide or was murdered after his trial in 29. Only two of her children are of historical importance: Agrippina the Younger and Gaius Julius Caesar Augustus Germanicus, who succeeded Tiberius under the name of Caligula. Despite Tiberius' enmity towards Caligula's elder brothers, he nonetheless made Caligula and his cousin Tiberius Gemellus joint heirs to his property.
A superficial assessment views Agrippina as the innocent victim of tyranny. In reality, however, Agrippina herself had done much to provoke her fate. Her constant dwelling on her birth (e.g. Annals 1.40) and her being the "sole surviving offspring of Augustus" (Annals 3.4) was not merely an insult to Tiberius, Augustus’ son by adoption, but also to Livia, who was Julia Augusta only by testamentary adoption; her attitude also implied a challenge to Tiberius' own position.