• Dis is short for Mandisa
• Dis is usually a proper name that may refer to a number of mythological people and places.
• dis- (also di-, dif-), a prefix that first appeared in English words in the Middle English period in words borrowed from French

Religion, mythology, and fiction

• Dis, the fictional city in The Divine Comedy that contains the lower circles of hell; also an alternate name for Lucifer in the same work
• Dis Pater, predecessor of Pluto in Roman Mythology and ancestor of the Gauls according to Roman thought
• Dís, singular of dísir, a group of minor goddesses in Norse mythology
• Pluto, as the alternative name "Dīs"
• Dís (Middle-earth), a female Dwarf from J. R. R. Tolkien's universe
• Dis (Humanx Commonwealth planet), a planet in Alan Dean Foster's Humanx Commonwealth milieu, known for extremely large waves. A surfer can ride a single "monster" for several hours. (Short story, "Surfeit".)
• Dis Astranagant, a mecha from the Super Robot Wars series.
• Dis is a fictional planet where most of the action of Harry Harrison's novel Planet of the Damned takes place.
• Dis is a city in The Dark Tower series by Stephen King. It is the last known location of The Orange Bend of the Rainbow.

Music

• "dis–", the opening theme song of the anime series Infinite Ryvius, performed by Mika Arisaka
• Dis-, a rock trio from Milwaukee, Wisconsin
• Drowned In Sound, a webzine concentrating on new music
• Dís, a soundtrack album by Icelandic composer Johann Johannsson
• "Chambers of Dis", a song by Florida death metal band Morbid Angel from their 1998 release Formulas Fatal to the Flesh
• The musical note D, in German nomenclature
• Dis, an album by Norwegian jazz musician Jan Garbarek

Computer topics

• "Dis", an interpreted programming language derived from Malbolge
• "Dis" (see Limbo programming language), the virtual machine in the Inferno operating system
• "DIS", Distributed Interactive Simulation
• DIS, Department of Intelligent Systems, Jožef Stefan Institute, Slovenia

Games

• "Dis", the name of the final boss level, in mission eight of episode three (Inferno) in the original Doom video game.
• "Dis" (see Baator), the second of the Nine Hells in the Dungeons & Dragons roleplaying game universe
• "Dis," a fictional city in the Altered Beast video game
• "Dis", an ally in the RPG Shin Megami Tensei: Nocturne.

Military

• The Defence Intelligence Staff, an element of the United Kingdom's Ministry of Defence

Acronyms and slang

• Distributed Interactive Simulation, a standard for conducting real-time platform-level wargaming across multiple host computers
• Deep inelastic scattering, which occurs when two particles scatter and one break up into its constiutents
• diss, African American Vernacular English slang meaning "to disrespect"
• Denmark's International Study Program, a study abroad program located in Copenhagen
• The Walt Disney Company, "DIS" is the company's NYSE symbol