DET (N,N-diethyltryptamine) or T-9 is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100mg without the aid of MAO inhibitors lasting about 2-4 hours.
The mechanism of action is thought to be serotonin receptor agonism
, much like other classic psychedelics
Though DET is a synthetic
compound with no known natural sources
it has been used with mycelium
of Psilocybe cubensis
to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin)
and 4-HO-DMT (Psilocin)
. Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.
Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic
properties. Researchers theorized that abnormal metabolites
of endogenous chemicals such as tryptamine
, and tryptophan
could be the explanation for mental disorders
, or psychosis
. With the progression of science and pharmacological
understanding this belief remains dismissed by most researchers.