DET (N,N-diethyltryptamine) or T-9 is a psychedelic drug closely related to DMT and 4-HO-DET. However, despite its structural similarity to DMT it is active orally around 50–100mg without the aid of MAO inhibitors lasting about 2-4 hours.

Pharmacology

The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics.

Biochemistry

Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET and 4-HO-DET, as opposed the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Isolation of the alkaloids resulted in 3.3% 4-HO-DET and 0.01-0.8% 4-PO-DET.

Psychosis model

Early studies of DET, as well as other psychedelics, mainly focused on the believed psychotomimetic properties. Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders as schizophrenia, or psychosis. With the progression of science and pharmacological understanding this belief remains dismissed by most researchers.

See also

• TiHKAL
• 5-MeO-DET
• 4-PO-DET (Ethocybin)
• Psychedelic tryptamines

References

External links

• Erowid DET Vault
• DET entry in TiHKAL