Psychology

• Depression (mood)
• Clinical depression, a diagnosed mental disorder characterized by a pervasive low mood

Economics

• Depression (economics), an economic downturn more severe than a recession
• Great Depression, a depression in the 1930s
• Long Depression, a depression in the 1800s, then called the Great Depression

Earth science

• Depression (geology), a sunken landform
• Depression (meteorology), a weather phenomenon
• Tropical depression, a class of cyclone

Physiology

• Depression (physiology), a reduction in a biological variable or the function of an organ
• Depression (kinesiology), a term for movement in an inferior direction

Music

• "Depress," a song by Eyehategod on the album In the Name of Suffering
• "Depression," a song by Black Flag on the album Damaged