It has been referred to frequently in subsequent literature. Nathaniel Hawthorne's tale The Celestial Railroad is a satirical contrast between Bunyan's A Pilgrim's Progress and Hawthorne's perception of the current state of society. In Emily Brontë's Wuthering Heights the character Mr. Heathcliff likens his son's state of depression to having been dropped "into a Slough of Despond". In Horatio Hornblower: The Even Chance, by C. S. Forester, Midshipman Archie Kennedy describes Hornblower's new home as "His Majesty's ship of the line Justinian, known elsewise among her intimates as the good ship Slough of Despond." In Mary McCarthy's novel The Group (1954), "Kay saw that [her husband, Harald] was sinking into a Slough of Despond (they had coined this name for his sudden, Scandinavian fits of depression)…" In Harlan Ellison's short story I Have No Mouth, and I Must Scream (1967) the last five surviving humans are tortured by a godlike artificial intelligence named AM. The narrator relates how, among other harrowing experiences, "We passed through the Slough of Despond.
An area of wetlands in Canada is named after this fictional construct, located on the Bruce Trail near Big Bay, Ontario, north of Owen Sound.