It is also referred to as chondroitin sulfate B, although it is no longer classified as a form of chondroitin sulfate by most sources.
An excess of Dermatan Sulfate in the Mitral Valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, Mitral Valve Prolapse (into the Left Ventricle) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification and eccentric (volume dependent or dilated) hypertrophy and eventually Left Heart failure if untreated.
Characterization of Dermatan Sulfate oligosaccharides: Their interaction with Heparin Cofactor II and anticoagulant activities
Jun 01, 2006; A-76 A. M. Halldorsdottir, L. Zhang, D. M. Tollelsen. Washington University School of Medicine, St. Louis. MO. Objective: To...