In 1741, Henry O'Brien, 8th Earl of Thomond died without issue and in his will left the entire Irish estates of the Earls of Thomond to his nephew Percy Wyndham, the younger son of his wife's sister. In compliance with the terms of his inheritance, Percy took the additional name of O'Brien and was created Earl of Thomond and Baron Ibracken in the second creation on 11 December 1756.
He was MP for the constituency of Taunton in Somerset from 1745 to 1747 when he was succeeded by his brother Sir Charles Wyndham.
When Percy died unmarried and without issue in 1774 the title again became extinct. The lands passed to his nephew George Wyndham, 3rd Earl of Egremont of Petworth House.