• College University, an animated Internet-based comedy series
• The ISO 639-1 code for Old Church Slavonic
• Combat Upgrade, from the MMORPG (Massively Multiplayer Online Role-playing Game) Star Wars: Galaxies by Sony Online Entertainment
• Copper, the chemical element with the symbol Cu
• See you (later), here CU being an internet slang abbreviation
• A Portuguese profanity word meaning anus.

In mathematics & science:

• Chemical Symbol for Copper
• Cumulus clouds
• Control unit
• CU (Powerline), an HVDC-powerline in the USA
• cubic in a variety of English customary units (cubic inch, cubic foot, etc.).

Referencing a place:

• .cu is Cuba's top-level domain country code.
• Cuba, ISO 3166, FIPS Pub 10-4 and obsolete NATO digram
• Old Church Slavonic: ISO 639 alpha-2 language code.
• Champaign-Urbana Metropolitan Area

In religion:

• Christian Union (students), a university or college student Christian group.

In film making:

• Close Up.

In entertainment:

• Cities Unlimited, the former name of a not yet released city building computer game from Monte Cristo, now called Cities XL.

As a company or organization:

• ChristianUnion, a political party in the Netherlands
• Consumers Union
• Credit union
• Cubana, an IATA airline designator

As a university:

• University of Calcutta (India)
• University of Cambridge (UK)
• University of Colorado at Boulder (US)
• Cameron University (US)
• Capilano University (Canada]
• Cardiff University (UK)
• Carleton University (Canada)
• Cedarville University (US)
• Chapman University (US)
• Charles University (CR, Prague)
• Chinese University of Hong Kong (Hong Kong)
• Chittagong University, Bangladesh
• Chulalongkorn University (Thailand)
• Clarkson University (US)
• Clemson University (US)
• University of Colorado (US)
• Colgate University (US)
• Columbia University (US)
• Concordia University (Canada)
• Cornell University (US)
• Cornerstone University (US)
• Cranfield University (UK)
• Creighton University (US)
• Chulalongkorn University (Thailand)