CRS can refer to:

Science and Technology

• Cambridge Reference Sequence, used in mitochondrial DNA testing
• Canada Remote Systems, a now-defunct bulletin board system based in Toronto
• Carrier Routing System, a large-scale core router, developed by Cisco Systems, Inc
• Cold Rolled Steel
• Congenital rubella syndrome, a disease passed from mother to fetus
• Computer Reservations System, (also called a Central Reservation System) a computerised system used to store and retrieve information and conduct transactions related to travel bookings.
• Coordinate Reference System, a system that allows coordinates to refer unambiguously to a position.

Groups and organisations

Co-operative

• Co-operative Retail Services, a former co-operative society in the United Kingdom

Christian

• Catholic Relief Services, an American international humanitarian agency
• Creation Research Society, a Christian research group that engages in creation science

Environment

• Center for Resource Solutions

Fictional

• Consumer Recreation Services, a fictional company from the 1997 film The Game.

Governmental

• Compagnies Républicaines de Sécurité, a French riot police force
• Congressional Research Service, the public policy research arm of the United States Congress
• NHS Care Records Service, the UK NHS Care Records Service

Music

• Child Rebel Soldier, a rap group whose members include Kanye West, Lupe Fiasco, and Pharrell

Private company

• Cornered Rat Software, a Texas based computer game software company
• Croatian Register of Shipping

Youth

• Camp Rising Sun, an international leadership program for youth development