Definitions

coxiella

Coxiella burnetii

Coxiella burnetii is a species of intracellular, pathogenic bacteria, and is the causative agent of Q fever. The genus Coxiella is morphologically similar to the rickettsia, but with a variety of genetic and physiological differences. C. burnetii are small Gram negative bacteria with two growth phases, as well as a spore form which lies idle in soil. It can survive standard disinfectants, and is resistant to many other environmental changes like those presented in the phagolysosome.

Pathogenesis

The LD50 (the dose needed to infect 50% of experimental subjects) is one via inhalation — i.e. inhalation of one organism will yield disease in 50% of the population. This is an extremely low infectious dose, making C. burnetii the most infectious organism known to man. Disease occurs in two stages: an acute stage that presents with headaches, chills, and respiratory symptoms, and an insidious chronic stage.

While most infections clear up spontaneously, treatment with tetracycline or doxycycline appears to reduce the symptomatic duration and reduce the likelihood of chronic infection. A combination of erythromycin and rifampin is highly effective in curing and prevention of disease and so is vaccination with Q-vax vaccine (CSL).

The bacteria use a Type IVB secretion system known as Icm/Dot to inject effector proteins called Ank proteins into the host. These effectors increase the bacteria's ability to survive inside the host cell. In Legionella pneumophila, which uses the same secretion system and also injects Ank proteins, survival is enhanced because these Ank proteins interfere with fusion of the bacteria-containing vacuole with the host's degradation endosomes.

References

External links

  • Coxiella (from PATRIC the PathoSystems Resource Integration Center, a NIAID Bioinformatics Resource Center)

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