"First Down" is the twenty-sixth episode of the television series Prison Break and is the fourth episode of its second season. It is written by Nick Santora and directed by Bobby Roth. The episode first aired in the United States on September 11, 2006. In regards to the casting of this episode, Amaury Nolasco (who plays Fernando Sucre), Marshall Allman (who plays L. J. Burrows) and Rockmond Dunbar (who plays Benjamin Miles "C-Note" Franklin) do not appear in this episode. This is the first episode to date in which Amaury Nolasco does not appear.
Lincoln spots a tail as he drives down a rural highway. Michael and Nika turn around to see Bellick and Geary following them. Geary speeds up next to their car and attempts to ram their car off the road. He succeeds in forcing their car down a ditch, hitting a tree. Bellick points his pistol at Lincoln, Michael and Nika as he tells Michael that he knows about the money in Utah and has decided to join them on their trip to pick up the money. Bellick forces them to get into his and Geary's car.
At the field office of the FBI in Chicago, one of Agent Mahone's subordinates informs him that 12 percent of the data from Michael's hard drive, which he dumped in the river, has been recovered. These included the newspaper clippings of Abruzzi, Sara and D. B. Cooper's money. Another agent then tells him about the positive match on the blood results - B negative, the same as Michael and Lincoln's blood type. Mahone becomes agitated and tells all the agents in the office to not to announce deaths until they are confirmed, and orders them to do more tests.
Bellick and Geary are forced to stop when one of their car tires go flat, which Lincoln had secretly stuck a shard of glass under. Bellick proceeds to tell Geary to go to the nearest town to buy a tire and force Michael, Lincoln and Nika into the neighbouring woods. Tied up in an isolated building, Lincoln tells Michael that he doesn't trust Nika. In the meantime, Nika negotiates with Bellick, convincing him that she wants Michael dead, that Michael was trying to set up Bellick in Panguitch, Utah, and that she will sleep with Bellick for a share of the money in Utah. Whilst seducing him, Nika tries to steal Bellick's gun. Bellick returns her to the other room and tells her not to try and fool him. As he walks away, he realizes his knife was stolen, as Lincoln frees himself and uses the knife against Bellick. Upon Geary's return, both Geary and Bellick are tied up. Bellick tells Michael about Sara's overdose.
Kellerman, posing as Lance, tells the other recovering addicts at a Narcotics Anonymous meeting an emotional story, about his mother dying of multiple sclerosis and hinting that he may inherit it, knowing it is not genetic and will attract attention from Sara. After the meeting, Kellerman approaches Sara and begins to talk with her, trying to befriend her. As they eat their pies, Sara receives a call from Michael. Michael begins to apologise for everything that has happened to Sara, who does not want to talk to him. He insistently tells her that there is a way he can protect her and "it" is already in her possession. Sara is confused about what he is talking about. Kellerman looks up after hearing Sara calling for Michael, who had hung up.
Tweener travels with Debra Jean in her Toyota Yaris, which was also extensively featured in the Prison Break mobisodes. When the radio talks about the Fox River Eight's escape, Tweener switches the radio to sing along - awkwardly to a John Denver song, Take Me Home, Country Roads. After Tweener spots a police officer, he tells Debra Jean to slow down even though she was only travelling at 65 miles per hour. Debra Jean becomes more suspicious of Tweener. Once the couple end up staying at The Lotus Motel in Mack, Colorado, Debra Jean relays her location on the phone to somebody.
T-Bag stops at a gas station in Friend, Nebraska. The police surround the SUV T-Bag stole from the murdered Dr. Gudat while he is in the station restroom. T-Bag pretends to be a former US Marine wounded in Kandahar, Afghanistan. He blames the stolen SUV on the "hippie" in the gas station restroom. The hippie was quickly taken into custody. Forced to abandon the SUV, he becomes a hitchhiker and is picked up by a man from the gas station and his teenage daughter (played by Demi Lovato). T-Bag makes a move on the mans daughter. The daughter tells the man about this and he attempts to attack T-Bag. T-Bag is able to knock out the man (possible killed him) and steals his station wagon and hat. Ultimately, he is seen by the man's daughter as he drove past her and her groceries; the two locked eyes, and the girl, knowing what this meant dropped her purchases and wept
In Brooklyn, New York, John Abruzzi reunites with his family. One of his mafia associates tells him that Otto Fibonacci is going to testify in Washington, D.C.. Abruzzi decides to get his revenge instead of hiding on a cargo ship back to Sardinia, Italy. When Abruzzi is informed of Fibonacci's location, he's told that the information is "from New Jersey; Fish-Head Tommy wants to pay tribute." The lead on Fibonacci turns out to be fake, a setup not unlike Fibonacci's set up upon him. Abruzzi decides to go down fighting, and is swiftly shot by Agent Mahone's men.
Michael, Lincoln and Nika prepare to leave. Michael tells Nika he can take her into town. However, Nika wants to go with them. At Michael's refusal, Nika relents and hugs him, bidding him farewell. As she hugs Lincoln, she reaches round to take the gun from Lincoln and points the gun at them. Nika confesses her love for Michael. She proceeds to use the cell phone to call the police but is stopped by Lincoln, who had pulled out the gun's magazine clip earlier. He takes the gun and cell phone from Nika and gets in the car. Michael sadly wishes Nika luck and joins his brother in the car. They drive off leaving Nika standing alone on the side of the road.
Mahone receives the results of the lab tests which proves that the blood from the crash site was that of a pig. Reminded of his previous failure to capture Oscar Shales, Mahone unleashes his fury on the picture of Michael and says ominously to it, "You have no idea what you're in for."