Definitions

Cosyntropin

Cosyntropin

Cosyntropin (tradename Cortrosyn) is a synthetic derivative of ACTH that is used in the ACTH stimulation test to evaluate and diagnose cortisol disorders. Cosyntropin contains the first 24 (of a total 39) amino acids of ACTH but retains full function.

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, cosyntropin can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of cosyntropin makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of cosyntropin rules out the condition.

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