Cosimo may refer to:

Popes:

• Pope Innocent VII (c. 1336–1406), born Cosimo de' Migliorati

Members of the Medici family:

• Cosimo de' Medici (1389–1464), ruler of Florence, Italy
• Cosimo di Giovanni de' Medici, any of several people of the same name
• Cosimo I de' Medici, Grand Duke of Tuscany (1519–1574)
• Cosimo II de' Medici, Grand Duke of Tuscany (1590–1621)
• Cosimo III de' Medici, Grand Duke of Tuscany (1642–1723)
• Ferdinando (III) de' Medici (1663–1713), hereditary prince of Tuscany
• Giovanni di Cosimo de' Medici (1421-1463), Italian banker
• Lorenzo di Cosimo de' Medici
• Lucrezia di Cosimo de Medici (1544–1561), daughter of Cosimo I de' Medici, Grand Duke of Tuscany
• Maria di Cosimo I de' Medici (1540-1557), daughter of Cosimo I de' Medici, Grand Duke of Tuscany
• Piero di Cosimo de' Medici (1416–1469), ruler of Florence

Articles related to the Medici family:

• Ancestors of Cosimo I de Medici in three generations
• Descendants of Cosimo I de Medici in three generations
• Portrait of a Man with a Medal of Cosimo the Elder, c. 1474-1475 painting by Sandro Botticelli
• Portrait of Cosimo I de' Medici, 1545 painting by Agnolo di Cosimo
• Statue of Cosimo I, 1596 statue in Pisa, Italy

People with the surname Cosimo:

• Agnolo di Cosimo (1503–1572), Florentine painter
• Piero di Cosimo (1462–1522), Italian painter

Works by Piero di Cosimo:

• Portrait of Simonetta Vespucci (Piero di Cosimo), c. 1480 painting by Piero di Cosimo
• The Myth of Prometheus (Piero di Cosimo), 1515 series of five panels by Piero di Cosimo

People with the given name Cosimo:

• Cosimo Bartoli (1503–1572), Italian diplomat and humanist
• Cosimo Boscaglia (c.1550–1621), Italian professor of philosophy
• Cosimo Caliandro (b. 1982), Italian middle distance runner
• Cosimo Cavallaro (b. 1961), Italian-Canadian artist
• Cosimo Commisso, any of several people of the same name
• Cosimo Daddi (before 1575-1630), Italian painter
• Cosimo della Rovere (1820-1900), Italian general
• Cosimo Fancelli (c. 1620-1688), Italian sculptor
• Cosimo Fanzago (1591-1678), Italian architect and sculptor
• Cosimo Lotti (1571-1643), Italian engineer
• Cosimo Matassa (b. 1926), Italian-American studio owner
• Cosimo Morelli (1732-1812), Italian architect
• Cosimo Mortola (b. 1977), Italian-American bush pilot, cartoonist
• Cosimo Perrotta, Italian professor of economic history
• Cosimo Pinto (b. 1943), Italian boxer
• Cosimo Rosselli (1439-after 1506), Italian painter
• Cosimo Tura (c. 1430-1495), Italian painter
• Cosimo Ulivelli (1625-1704), Italian painter