Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer's disease, and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially-fatal metabolic consequences including hypoglycemia and hepatitis. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.
α-helical CRH-(9–41) acts as a CRH antagonist.
Also, abnormal levels of CRH have been found in the cerebrospinal fluid of suicide victims.
Recent research has linked the activation of the CRH1 receptor with the euphoric feelings that accompany alcohol consumption. A CRH1 receptor antagonist developed by Pfizer, CP-154,526 is under investigation for the potential treatment of alcoholism.
Levels rise towards birth and current theory suggests three roles of CRH in parturition:
In culture, trophoblast CRH is inhibited by progesterone, which remains high throughout pregnancy. Its release is stimultated by glucocorticoids and catecholamines, which increase prior to parturition lifting this progesterone block.
US Patent Issued to Warner Chilcott on March 1 for "Corticotropin Releasing Factor 2 Receptor Agonists" (Ohio Inventors)
Mar 07, 2011; ALEXANDRIA, Va., March 7 -- United States Patent no. 7,897,731, issued on March 1, was assigned to Warner Chilcott Co. LLC...
Patent No. 7,608,701 Issued on Oct. 27, Assigned to The Procter & Gamble for Corticotropin Releasing Factor (U.S. Inventors)
Oct 29, 2009; ALEXANDRIA, Va., Oct. 29 -- Robert Joseph Isfort of Fairfield, Ohio, and Wieslaw Adam Mazur of Mason, Ohio, have developed a...