The corpus luteum is typically very large relative to the size of the ovary; in humans, the size of the structure ranges from under 2 mm to 5 mm in diameter.
Its cells develop from the follicular cells surrounding the ovarian follicle:
|The granulosa cells||the inner granulosa lutein layer||progesterone|
|Theca cells||the outer theca lutein layer||estrogen, androgens|
The uterine lining sloughs off without progesterone and is expelled through the vagina (in humans and some great apes, which go through a menstrual cycle). In an estrus cycle, the lining degenerates back to normal size.
Human chorionic gonadotropin signals the corpus luteum to continue progesterone secretion, thereby maintaining the thick lining (endometrium) of the uterus, and providing an area rich in blood vessels in which the zygote(s) can develop. From this point on, the corpus luteum is called the corpus luteum graviditatis.
The introduction of prostaglandins at this point causes the degeneration of the corpus luteum and the abortion of the fetus. However, in placental animals such as humans, the placenta eventually takes over progesterone production and the corpus luteum degrades into a corpus albicans without embryo/fetus loss.
New corpus luteum study findings recently were reported by researchers at Hokkaido University, Department of Anatomy.(Report)
Aug 10, 2010; Data detailed in 'Differential cellular localization of galectin-1 and galectin-3 in the regressing corpus luteum of mice and...
Wipo Publishes Patent of Omron Healthcare for "Corpus Luteum Function Evaluation Device, Corpus Luteum Function Evaluation System and Methods for Said Evaluation" (Japanese Inventors)
Nov 08, 2013; GENEVA, Nov. 8 -- Publication No. WO/2013/164974 was published on Nov. 7.Title of the invention: "CORPUS LUTEUM FUNCTION...