Plato made her film debut in Return to Boggy Creek. Other credits include California Suite and Exorcist II: The Heretic.
Dana trained as a figure skater and was quite accomplished. She was training for a possible Olympic team spot (she later claimed that she qualified for the team). At the same time, however, she was spotted by a television producer during a brief appearance on The Gong Show and won what would become her most famous acting role. According to Dana, Kay Plato decided she should cut back on her skating to focus on her portrayal of Kimberly Drummond on Diff'rent Strokes.
The show was an immediate hit. Even though she was a supporting character, Plato claimed to have made up to US$100,000 an episode during its peak. (Some sources suggest, however, that US$22,000 might be a more representative figure.). However, in an episode of E!'s show True Hollywood Story on Plato, it was reported that she made $50,000 an episode.
Plato appeared on the show until 1984. During that year, she got pregnant by her boyfriend, a musician named Lanny Lambert. The producers of Diff'rent Strokes did not feel that a pregnancy would fit the show's wholesome image, so Plato was let go. Although rumors of drug use and other "problems on the set" swirled around her dismissal, the producers were adamant that the pregnancy was the only reason her character was written out. Plato actually returned for several appearances during the show's final season, which appeared on ABC, including an episode in which Kimberly suffers the effects of bulimia.
In 1992, Plato was one of the first celebrities to star in a video game. The game, Night Trap, was universally panned by critics and attracted much controversy (the secondary reason the ESRB exists today) over a scene of a girl in a nightgown being killed, although that scene was considered to have been in the comedic vein of the entire game. Plato's career took another hit from the attitudes toward the game.
In 1994, Plato underwent additional plastic surgery to further enhance her breasts, in the hopes of landing more significant film roles. She also acquired several tattoos, including a dove on the back of her left shoulder, a winged fairy and a star above her groin, and flowers on her feet.
Toward the end of her career, Plato chose roles that could be considered erotic or even softcore pornography. She appeared partially nude in Prime Suspect (1988) and Compelling Evidence (1995), but her most infamous picture is 1997's Different Strokes: The Story of Jack and Jill...and Jill. The movie's title was changed after shooting to tie it to Plato's famous past, but was not connected in any way to the sitcom other than through her involvement. Plato played a lesbian, and the film was rated X due to sexual content, but it was not considered hardcore pornography. Plato would appear in only one more film.
Plato began having drug and alcohol problems early in life. At age 14, she overdosed on Valium. She also, by her own admission, drank and used recreational drugs during her years on Diff'rent Strokes.
In 1988, Plato's adoptive mother, Kay, died from scleroderma. Shortly thereafter, Plato's marriage to Lanny Lambert began to fall apart. The couple officially divorced in 1990, with Lambert getting custody of their only child, Tyler (born 1985). During this time, Plato posed nude for Playboy, appearing in the June 1989 issue. The issue was also notable for featuring Hugh Hefner's new wife, Kimberley Conrad.
In 1991, Plato ended up in Las Vegas with no work. She took a job at a dry-cleaning store to support herself. One day, she entered a video store, produced a gun, and demanded the money from the register. She was arrested minutes later. Las Vegas entertainer Wayne Newton posted her US$13,000 bail bond. Plato was given five years probation. The gun was only a pellet gun and the robbery netted Plato less than US$200. She made headlines and became part of the national debate over troubled child stars, particularly given the difficulties of her Diff'rent Strokes co-stars, Gary Coleman and Todd Bridges. In January 1992, she was again arrested, this time for forging a prescription for Valium. She served 30 days in jail for violation of the terms of her probation and entered a drug program immediately thereafter.
Following her appearance in the erotic film Different Strokes: The Story of Jack and Jill...and Jill, Plato appeared on the cover of the lesbian lifestyle magazine, Girlfriends, in 1998. She was interviewed by Diane Anderson-Minshall and came out as a lesbian, although she later recanted. It was reported that Plato showed up drunk for the magazine's cover shoot.
In her interview with Howard Stern, Plato mentioned that the traumatic events of her mother's death and her husband leaving her took place during the course of only a week. In desperation, she signed over power of attorney to an accountant who absconded with the majority of her money, leaving her with no more than US$150,000. She claimed that the accountant was never found, despite an exhaustive search, and had stolen a grand total of more than US$11 million of other people's money, as well.
Just before her death, she and her fiancé, Robert Menchaca, were living in an RV in Navarre, Florida.
The next day, Plato and Menchaca were returning to California, hoping to revive her stagnant career. The couple stopped at Menchaca's mother's home in Moore, Oklahoma (coincidentally, the birthplace of another Diff'rent Strokes cast member, Danny Cooksey) for a Mother's Day visit. Plato went to lie down inside her recreational vehicle parked outside the house and subsequently died of an overdose from Vanadom (Soma) and Vicodin. Her death at the early age of 35 was eventually ruled a suicide. Subsequently both Gary Coleman and Todd Bridges, who remained friends with Plato after Diff'rent Strokes, have said they do not believe she intended to kill herself, and that they believe it was an accidental overdose.
Much confusion remains about her precise age. Oklahoma authorities, presumably taking the information from Plato's Florida driver's license, determined her birthdate to be November 1, 1963, making her 35 when she died, while many news sources reported that she was born on November 7, 1964. Plato claimed that she was only 34 years old at one point during her Howard Stern appearance, which took place one day before she died. Her body was cremated and her ashes were scattered over the Pacific Ocean.
She was also mentioned on E!'s 50 Greatest Child Stars.