Charles Darwin gave new direction to morphology and physiology, by uniting them in a common biological theory: the theory of organic evolution. The result was a reconstruction of the classification of animals upon a genealogical basis, fresh investigation of the development of animals, and early attempts to determine their genetic relationships.
In the first hybrid generation, nearly all the individuals had the positive character, but in subsequent generations the positive character was not present in all individuals: half had the character and half did not. Thus the random pairing of two groups of reproductive cells yielded the proportion 1 PP, 2 PN, 1 NN, where P stands for the character and N for its absence - the character was present in three-quarters of the offspring and absent from a quarter. The failure of the character to distribute itself among all of the reproductive cells of a hybrid individual, and the limitation of its distribution to half only of those cells, prevents the swamping of a new character by interbreeding. The tendency of the proportions in the offspring is to give, in a series of generations, a reversion from the hybrid form PN to a race with the positive character and a race without it. This tendency favours the persistence of a new character of large volume suddenly appearing in a stock. The observations of Mendel thus favoured the view that the variations upon which natural selection acts are not small but large and discontinuous. However, it did not appear that large variations would be favoured any more than small ones, or that the eliminating action of natural selection upon an unfavourable variation could be checked.
Much confusion arose in discussions of this topic, because of defective nomenclature. Some authors used the word mutation only for large variations that appeared suddenly and which could be inherited, and fluctuation for small variations, whether they could be transmitted or not. Other authors used fluctuation only for small, acquired variations due to changes in food, moisture and other features of the environment. This kind of variation is not heritable, but the small variations to which Darwin attached importance are. The best classification of the variations in organisms separates those which arise from congenital variations from those which arise from variations of the environment or the food-supply. The former are innate variations, the latter are "acquired variations". Both innate and acquired variations include some which are more and some which are less obvious. There are slight innate variations in every new generation of every species; their greatness or smallness so far as human perception goes is not of much significance, their importance for the origin of new species depends on whether they are valuable to the organism in the struggle for existence and reproduction. An imperceptible physiological difference might be of selective value, and it might carry with it correlated variations which may or may not appeal to the human eye but which are of no selective value themselves.
The views of Hugo de Vries and others about the importance of saltatory variation, the soundness of which was still not generally accepted in 1910, may be gathered from the article Mendelism. A due appreciation of the far-reaching results of correlated variation must, it appeared, give a new and distinct explanation of large mutations, discontinuous variation, and saltatory evolution. The analysis of the specific variations of organic form to determine the nature and limitation of a single character, and whether two variations of a structural unit can blend when one is transmitted by the male parent and the other by the female, were yet to be determined. It was not clear whether absolute blending was possible, or whether all apparent blending was only a more-or-less minutely subdivided mosaic of non-combinable characters of the parents.
Another important development of Darwin's conclusions deserves notice. The fact of variation was familiar: no two animals, even of the same brood, are alike. Jean-Baptiste Lamarck hypothesised that structural alterations acquired by a parent might be transmitted to the offspring, and as these are acquired by an animal or plant as a consequence of the action of the environment, the offspring would sometimes start with a greater fitness for those conditions than its parents started with. In turn, it would acquire a greater development of the same modification, which it would transmit to its offspring. Lamarck argued that, over several generations, a structural alteration might thus be acquired. The familiar illustration of Lamarck's hypothesis is that of the giraffe, whose long neck might, he suggested, was acquired by the efforts of a short-necked race of herbivores who stretched their necks to reach the foliage of trees in a land where grass was deficient, the effort producing a longer neck of each generation, which was then transmitted to the next. This process is known as 'direct adaptation'.
Such structural adaptations are acquired by an animal in the course of its life, but are limited in degree and rare, rather than frequent and obvious. Whether acquired characters could be transmitted to the next generation was a very different issue. Darwin excluded any assumption of the transmission of acquired characters. He pointed to the fact of congenital variation, and showed that congenital variations are arbitrary and non-significant.
After Darwin's writings, there was an effort to find evidence for the transmission of acquired characters; ultimately, the Lamarckian hypothesis of transmission of acquired characters was not supported by evidence, and was dismissed. August Weismann argued from the structure of the egg-cell and sperm-cell, and from how and when they are derived in the growth of the embryo from the egg, that it was impossible that a change in parental structure could produce a representative change in the germ or sperm-cells.
The only evidence that seemed to support the Lamarckian hypothesis were the experiments of Charles Brown-Séquard, who produced epijeptilism in guinea-pigeptys by bisection of the large nerves or spinal cord, which led him to believe that, in rare instances, the artificially-produced epilepsy and mutilation of the nerves was transmitted. The record of Brown-Séquard's original experiments was unsatisfactory, and attempts reproduce them were unsuccessful. Conversely, the vast number of experiments in the cropping of the tails and ears of domestic animals, as well as of similar operations on man, had negative results. Stories of tailess kittens, puppies, and calves, born from parents one of whom had been thus injured, are abundant, but failed to stand experimental examination.
Whilst evidence of the transmission of an acquired character proved wanting, the a priori arguments in its favour were recognized as flawed, and cases which appeared to favour the Lamarckian assumption were found to be better explained by the Darwinian principle. For example, the occurrence of blind animals in caves and in the deep sea was a fact which even Darwin regarded as best-explained by the atrophy of the eye in successive generations through the absence of light and consequent disuse. However, it was suggested that this is better explained by natural selection acting on congenital fortuitous variations. Some animals are born with distorted or defective eyes. If a number of some species of fish are swept into a cavern, those with perfect eyes would follow the light and eventually escape, leaving behind those with imperfect eyes to breed in the dark place. In every succeeding generation this would be the case, and even those with weak but still seeing eyes would escape, until only a pure race of blind animals would be left in the cavern.
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