• Saint Kitts and Nevis, NATO country code
• Seychelles, ISO 3166-1 alpha-2 country code, SC
• South Carolina, United States postal abbreviation
• Sumter and Choctaw Railway
• Shandong Airlines, IATA airline designator
• Santa Catarina (state), Brazil (ISO 3166-2:BR)
• A USCS symbol for clayey sand

In medicine:

• Secretory component
• Stem cell
• Subcutaneous
• Superior colliculus

In computer, video games, and television:

• SimCity, a computer game
• Soulcalibur, Namco's popular fighting game series
• Splinter Cell, a computer game by Ubisoft
• Star Control, computer game
• StarCraft, computer game
• Steambot Chronicles
• Strike Commander, computer game
• Supreme Commander, computer game
• Sven Co-op, A Half-Life modification
• Sandy Cheeks, character in SpongeBob SquarePants
• Sally Carrera, character in Cars and Cars 2

SC may also be:

• Science Channel
• Cruiser Submarine, US Navy hull classification
• Safety Car, a vehicle which controls the speed of competitors in an automobile race for safety reasons
• Santa Cruz
• Sam's Club
• Samurai Champloo
• Scheduled castes, the disadvantaged castes of India commonly known as Dalits
• The United Nations Security Council
• A United Nations Security Clearance
• Senior Counsel
• Sha Tin College, an ESF (English Schools Foundation) school in Sha Tin, Hong Kong. Also registered IB world school
• Shortcut
• Short course, swimming in a 25 m pool
• Simplified Chinese
• Skate Canada
• SmarterChild, an AOL Instant Messenger bot
• Smithtown Christian School
• Soccer Club (in some countries it may stand for Sports Club, but the main sport played may still be soccer)
• Solar cell
• Space Cowboy
• Special Circumstances
• Special Constable
• Spice Channel
• SportsCenter, An American Sports show
• SportsCentre, A Canadian Sports show
• Springfield College
• Star of Courage
• Star of Courage (Australia) (Australian decoration)
• Star of Courage (Canadian decoration post-nominal letters)
• Stone Cold Steve Austin
• Sternoclavicular joint of the human body and other animals
• Suicide Chess
• The Supreme Court, in some countries
• University of South Carolina
• University of Southern California
• A type (SC) of optical fiber connector, of a push-pull coupling style
• The School Certificate, an accreditation issued by the New South Wales Board of Studies, typically at the completion of Year 10
• Lexus SC, the mid-sized coupe from made by Lexus
• Service Corporation in Wisconsin, similar to Professional Associations (PA) or Professional Corporation (PC) in some other states

Sc may refer to:

• Scandium (Sc symbol for the chemical element)
• Schmidt number, in fluid dynamics
• Sc, the abbreviation for the orchid genus Sophrocattleya

sc may refer to:

• Sardinian language (ISO 639 alpha-2, sc)
• strip club
• SuperCollider programming language
• saltwater crocodile

sc is a digraph in some languages

• in Italian and some closely related languages, and also in Old English it makes the voiceless postalveolar fricative [ʃ] sound

sc. is an abbreviation of

• scilicet