Medawar

Medawar, Sir Peter Brian, 1915-87, British zoologist, b. Brazil. After graduate work at Oxford, he held research and teaching posts there. He was professor of zoology (1947-51) at the Univ. of Birmingham and in 1951 became professor of zoology and comparative anatomy at University College, London. During World War II, he discovered a method for joining ends of severed nerves; he later became noted for his experimental work in transplanting living tissue from one body to another. Working on a theory proposed by Sir Macfarlane Burnet, he proved it was possible under certain circumstances for an organism to overcome its normal tendency to reject foreign tissue or organs. Medawar was awarded the 1960 Nobel Prize for Physiology or Medicine jointly with Sir Macfarlane Burnet for this discovery of acquired immunological tolerance. He was knighted in 1965. A prolific writer, his works include The Art of the Soluble (1967), Advice to a Young Scientist (1979), and an autobiography (1986).

(born Feb. 28, 1915, Rio de Janeiro, Braz.—died Oct. 2, 1987, London, Eng.) Brazilian-born British zoologist. Educated at Oxford, he began transplant research in 1949. His finding (1953) that adult animals injected with foreign cells early in life accept skin grafts from the original donor or its twin lent support to Macfarlane Burnet's hypothesis that cells learn, during and just after birth, to distinguish “own” from “foreign.” He found that nonidentical cattle twins accept skin grafts from each other, proving that antigens “leak” between the embryos' yolk sacs, and showed with mice that each cell contains genetic antigens important to immunity. His work deflected immunology from dealing with the fully developed immunity mechanism to attempting to alter the mechanism itself (e.g., suppression of transplant rejection). He and Burnet shared a 1960 Nobel Prize.

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(born Feb. 28, 1915, Rio de Janeiro, Braz.—died Oct. 2, 1987, London, Eng.) Brazilian-born British zoologist. Educated at Oxford, he began transplant research in 1949. His finding (1953) that adult animals injected with foreign cells early in life accept skin grafts from the original donor or its twin lent support to Macfarlane Burnet's hypothesis that cells learn, during and just after birth, to distinguish “own” from “foreign.” He found that nonidentical cattle twins accept skin grafts from each other, proving that antigens “leak” between the embryos' yolk sacs, and showed with mice that each cell contains genetic antigens important to immunity. His work deflected immunology from dealing with the fully developed immunity mechanism to attempting to alter the mechanism itself (e.g., suppression of transplant rejection). He and Burnet shared a 1960 Nobel Prize.

Learn more about Medawar, Sir Peter B(rian) with a free trial on Britannica.com.

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