Antofagasta de la Sierra is the northernmost department of Catamarca Province in Argentina.
The provincial subdivision has a population of about 1,300 inhabitants in an area of 28,097km², and its capital city is Antofagasta de la Sierra.
The department is most famous for its volcanic activity, there are over 200 volcanos situated in the area, the most notable of them are Antofagasta, Antofalla, Carachi Pampa, Alumbrera and Galán.
The Galán volcano has the largest explosive Caldera in the world.