2 City (1990 pop. 69,101), seat of Boone co., central Mo.; inc. 1826. The trade center of a farm and coal area, it has some light manufacturing but is best known as the seat of the Univ. of Missouri and Stephens College. The city is a medical center, with the university hospital, a state cancer hospital, a state regional mental health center, and a veterans' hospital. Houses in the city date from c.1820.
3 City (1990 pop. 98,052), state capital, and seat of Richland co., central S.C., at the head of navigation on the Congaree River; inc. 1805. It is the largest city in the state and an important trade and commercial point in the heart of a fertile farm region. Its industries include boatbuilding and the manufacture of electric equipment, paper and metal products, stainless steel, and apparel. A trading post flourished nearby in the early 18th cent. In 1786 the site was chosen for the new state capital because of its central location; the legislature first met in its new quarters in 1790. During the Civil War, General Sherman's army entered Columbia on Feb. 17, 1865. That night the city was burned and almost totally destroyed by drunken Union soldiers. An educational center, Columbia is the seat of the Univ. of South Carolina, Benedict College, Columbia College, Allen Univ., and Columbia International Univ. Notable buildings include the statehouse (begun 1855, damaged in 1865, completed 1901), President Woodrow Wilson's boyhood home (1870), and several antebellum houses. Also of interest are the South Carolina Archives Building; the Columbia Museum of Art and Science; the Midlands Exposition Park, with historical exhibits; and a zoo. Adjacent to the city is U.S. Fort Jackson, a major infantry training center. Lake Murray (formed by the dammed Saluda River) and Congaree National Park are nearby.
4 City (1990 pop. 28,583), seat of Maury co., central Tenn., on the Duck River; inc. 1817. Once a noted mule market and racing horse center, it is the trade and processing hub of a fertile area producing beef cattle and burley tobacco, as well as a shipping point for the region's limestone and phosphate deposits. Columbia has many fine antebellum homes, such as the James K. Polk House (1816). A national jubilee for Tennessee walking horses is annually held in June.
The Columbia River has created regal gorges by cutting through the Cascades and the Coast Ranges; it is fed by the Cowlitz and Willamette rivers, which drain the Puget trough between those ranges. Grand Coulee, now a reservoir in the Columbia basin project, was a former stream channel of the Columbia River. It was created during the last ice age when the Columbia's course was blocked by ice, forcing it to cut a new channel through the Columbia Plateau. When the ice receded the river resumed its former channel.
The Columbia River, commanding one of the great drainage basins of North America (c.259,000 sq mi/670,800 sq km), was visited by Robert Gray, an American explorer, in 1792 and is named for his vessel, the Columbia. It was entered by a British naval officer, William R. Broughton, later the same year. Long before this time Native Americans were fishing salmon from the river; today fish are still caught there, but heavy settlement along the river and its tributaries, the construction of dams, and human use have reduced the salmon runs.
The first whites to arrive overland were the members of the Lewis and Clark expedition and the fur traders (notably David Thompson of the North West Company and the founders of Astoria). The river was the focus of the American settlement that created Oregon, and the river was itself sometimes called the Oregon River or the River of the West. Irrigation was begun early, and some tributaries were used to water cropland and orchards, as in the valleys of the Wenatchee and Yakima rivers.
After 1932 plans gradually developed to use the Columbia River to its ultimate possibility, and the Columbia basin project was established. Its purpose is to establish flood control, which would alleviate the destruction seen in the Columbia's greatest flood, that of 1894, and somewhat lesser but damaging floods, such as that of 1948; to improve navigation; to extend irrigation in order to make optimum use of the water of the Columbia and its tributaries; and to produce hydroelectric power to supply the Pacific Northwest.
There are six federal and five nonfederal dams on the Columbia River. Grand Coulee Dam (the key unit of the Columbia basin project) and Chief Joseph Dam, on the river's upper course, provide power, flood control, and irrigation. Priest Rapids, Wanapum, Rock Island, Rocky Reaches, and Wells dams are on the middle course; all are among the largest nonfederal hydroelectric facilities in the United States. Bonneville, The Dalles, John Day, and McNary dams, on the lower course, were designed as power, flood control, and navigation projects; these dams provide a 328-mi (528-km) slack-water navigation channel up the Columbia River from the Pacific Ocean to the Snake River. With these federal projects and nonfederal dams on the Columbia, hydroelectric plants on the river have a potential generating capacity of about 21 million kW. The development of hydroelectric power has had a significant effect on the economic pattern of the Pacific Northwest.
See J. V. Krutilla, The Columbia River Treaty; The Economics of an International River Basin Development (1967); J. E. Allen and M. Burns, Cataclysms of the Columbia (1987); W. Dietrich, The Great Columbia River (1995); R. White, The Organic Machine (1995).
Inquiries into the accident were undertaken by NASA, Congress, and an independent investigation board. Ultimately, it was determined that a large piece of foam insulation had broken off the external tank 82 seconds into liftoff and struck the leading edge of the shuttle's left wing, creating a hole in the wing. On reentry, the searing heat generated by friction entered the damaged wing, which then melted, destabilizing the shuttle and causing it to break up. The independent investigative panel was harshly critical of NASA and called for numerous reforms, most to repair NASA's "broken safety culture." Shuttle flights did not resume until July, 2005.
See P. Chien, Columbia: Final Voyage (2006).
City (pop., 2000: 572,059), capital of the U.S. It is coextensive with the District of Columbia. Situated at the navigational head of the Potomac River, between Maryland and Virginia, it has an area of 69 sq mi (179 sq km). The site was chosen by George Washington in 1790 as a political compromise that satisfied both Northern and Southern states. Designed by Pierre-Charles L'Enfant, it is one of the few cities in the world planned expressly as a national capital. The federal government occupied it in 1800. British troops burned the city (1814) during the War of 1812. With the annexation of Georgetown in 1878, the city became coterminous with the District of Columbia. Significant buildings include the Capitol, White House, and Library of Congress. The Washington Monument, Lincoln Memorial, Jefferson Memorial, and Vietnam Veterans Memorial are among the most famous of the city's more than 300 memorials and statues. The Smithsonian Institution is in Washington, as are numerous other cultural and educational institutions and foreign embassies. The economy is based on national and international political activities, scientific research, and tourism.
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Private university in New York City, a traditional member of the Ivy League. Founded in 1754 as King's College, it was renamed Columbia College when it reopened in 1784 after the American Revolution. It became Columbia University in 1912. Its liberal arts college began admitting women in 1983. Neighbouring Barnard College, founded in 1889 and part of the university since 1900, remains a women's liberal arts school; most courses are open to students of both colleges. From the outset Columbia differed from other private Eastern universities in its emphasis on such subjects as nature study, commerce, history, and government. It has strong graduate programs in the arts and sciences and several notable research institutes. Among its professional schools are those of architecture, business, education (Teachers College, Columbia University), engineering, international and public affairs, journalism, law, medicine (including affiliations with Columbia-Presbyterian Medical Center and NewYork-Presbyterian Hospital), nursing, public health, and social work.
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City (pop., 2000: 116,278), capital of South Carolina, U.S. Located in the centre of the state on the Congaree River, it dates from 1786, when a town was laid out to replace Charleston as the state capital. During the American Civil War, it was a transportation centre and the seat of many Confederate agencies; in 1865 it was occupied by Union troops and virtually destroyed by fire. Rebuilt after the war, it developed a diversified economy based on government, industry, and agriculture. Cotton, peaches, and tobacco are important crops in the surrounding area. It is the seat of the University of South Carolina.
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Coast Mountains along the Torres Channel, an arm of Atlin Lake, northern British Columbia.
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Columbia was settled in Pre-Columbian times by the mound building Mississippian culture of Native Americans. In 1818, a group of settlers incorporated under the Smithton Land Company purchased over 2,000 acres (8 km²) and established the village of Smithton near present-day downtown Columbia. In 1821, the settlers moved and re-named the settlement Columbia—a poetic name for the United States. The founding of the University of Missouri in 1839 established the city as a center of education and research. By 1851, two other institutions of higher education, Stephens College and Columbia College were established within the city.
Located among small tributary valleys of the Missouri River, Columbia is roughly equidistant from St. Louis and Kansas City. Today, Columbia has a highly diversified economy, and is often ranked high for its business atmosphere. Never a strong center of industry and manufacturing, the city's economic base relies on the education, medical, technology and insurance industries. Studies consistently rank Columbia as a top city in which to live for educational facilities, health care, technological savvy, economic growth, cultural opportunities and cost of living. The city has been ranked as high as the second-best place to live in the United States by Money Magazine's annual list and is regularly in the top 100. Residents of Columbia are usually described as "Columbians.
The Columbia area was once part of the Mississippian culture and home to the Mound Builders. When European explorers arrived, the area was populated by the Osage and Missouri Indians. In 1678, La Salle claimed all of Missouri for France. The Lewis and Clark Expedition passed by the area on the Missouri River in 1803. In 1806, Daniel Boone and his sons established a salt lick northwest of Columbia. The Booneslick Trail wound from Kentucky through St. Charles to the lick. In 1818, a group of settlers, incorporated under the Smithton Land Company, purchased over 2,000 acres (8 km²) and established the village of Smithton less than a mile from current day downtown Columbia. In 1821, the settlers moved, because of lack of water, across the Flat Branch to the plateau between the Flat Branch and Hinkson creeks in what is now the downtown district. They re-named the settlement Columbia—a popular historical name for the United States.
The roots of Columbia's three economic foundations—education, medicine, and insurance—can be traced back to incorporation in 1821. Original plans for the town set aside land for a state university. Columbia College (distinct from today's), later to become The University of Missouri, was founded in 1833. When the state legislature decided to establish a state university, Columbia raised three times as much money as any other competing city and James S. Rollins donated the land that is today the Francis Quadrangle. Soon other educational institutions were founded in Columbia such as Christian Female College, the first college for women west of the Mississippi, which later became the current Columbia College. In 1856, Columbia Baptist Female College opened, which later became Stephens College. The city benefited from being a stagecoach stop of the Santa Fe and Oregon trails, and later from the Missouri-Kansas-Texas Railroad. In 1822 the first hospital was set up by William Jewell. In 1830, the first newspaper began; in 1832, the first theater in the state was opened; and in 1835, the state's first agricultural fair was held. By 1839, the population (13,000) and wealth of Boone County was exceeded in Missouri only by that of St. Louis County, which at that time included the City of St. Louis.
Columbia's infrastructure was wholly untouched by the Civil War. Missouri, as a slave state, had Southern sympathies, but remained in the union. The majority of the city was pro-union, however, the surrounding agricultural areas of Boone County and the rest of central Missouri were decidedly pro-slavery. Because of this, the University of Missouri became a base from which union troops operated. No battles were fought within the city because the presence of union troop dissuaded the confederate guerrillas from attacking, though several major battles occurred nearby at Boonville and Centralia.
In 1963, Columbia become home to the headquarters of both the University of Missouri System, which today serves over 60,000 students, and the Columbia College system, which today serves about 25,000 students. The insurance industry also became important to the local economy as several companies established headquarters in Columbia, including Shelter Insurance, Missouri Employers Mutual, and Columbia Insurance Group. State Farm Insurance has a regional office in Columbia. In addition, the now defunct Silvey Insurance was once a large local employer. Columbia became a transportation crossroads when U.S. Route 63 and U.S. Route 40 (which became present-day Interstate 70) were routed through the city. Soon after the city opened the Columbia Regional Airport. The latter 20th century saw tremendous growth, and by the end of the century the population was over 80,000 in the city proper.
In early 2006, Columbia embarked on a plan to manage the continued growth as the city nears 100,000 population. The city is today growing especially towards the Missouri River in southwest Boone County. The downtown district has maintained its status as a cultural center and is undergoing significant development in both residential and commercial sectors. The University of Missouri, which has tremendous economic impact on the city, experienced record enrollment in 2006 and is undertaking significant construction. The city experienced a violent crime spike in late 2007, and the city's growth is often cited as a contributing factor.
Columbia, located in the center of Missouri, is 120 miles away from both St. Louis and Kansas City, and 20 miles north of the state capital Jefferson City. The city is near the Missouri River between the Ozark Plateau and the Northern Plains. Trees are mainly oak, maple, and hickory; common understory trees include Eastern Redbud, Serviceberry, and Flowering Dogwood. Riparian areas are forested with mainly American sycamore. Much of the residential area of the city is planted with large native shade trees. In Autumn, the changing color of the trees is notable. Most species here are typical of the Eastern Woodland.
The city generally slopes from the highest point in the Northeast to the lowest point in the Southwest towards the Missouri River. Prominent tributaries of the river are Perche Creek, Hinkson Creek, and Flat Branch Creek. Along these, and other creeks in the area can be found large valleys, cliffs, and cave systems such as that in Rock Bridge State Park just south of the city. These creeks are largely responsible for numerous stream valleys giving Columbia hilly terrain similar to the Ozarks while also having flatland typical of northern Missouri. The city operates several greenbelts with trails and parks throughout the city. According to the United States Census Bureau, the city has a total area of 53.3 square miles (138.1 km²), of which, 53.1 square miles (137.5 km²) of it is land and 0.3 square miles (0.7 km²) of it (0.51%) is water.
Large mammals found in the city include urbanized coyotes and numerous whitetail deer. Eastern Gray Squirrel, and other rodents are abundant, as well as Cottontail rabbits and the nocturnal Opossum. Large bird species are abundant in parks and include the Canadian goose, Mallard duck, as well as shorebirds, including the Great Egret and Great Blue Heron. Turkeys are also common in wooded areas and can occasionally be seen on the MKT recreation trail. Populations of Bald Eagles are found by the Missouri River. The city is on the Mississippi Flyway, used by migrating birds, and has a large variety of small bird species, common to the eastern U.S. The Eurasian Tree Sparrow, an introduced species, is limited in North America to the counties surrounding St. Louis. Columbia has large areas of forested and open land and many of these areas are home to wildlife.
Frogs are commonly found in the springtime, especially after extensive wet periods. Common species include the American toad and species of chorus frogs, commonly called "spring peepers" that are found in nearly every pond. Some years have outbreaks of cicadas or ladybugs. Mosquitos and houseflies are common insect nuisances; because of this, windows are nearly universally fitted with screens, and "screened-in" porches are common in homes of the area.
Columbia's most commonly recognizable architectural attributes reside downtown and within the university campuses. Widely used icons of the city are the University of Missouri's Jesse Hall and the neo-gothic Memorial Union. The David R. Francis Quadrangle an example of Thomas Jefferson's academic village concept. There are four National Historic Districts within the city: Downtown Columbia, East Campus Neighborhood, Francis Quadrangle, and North Ninth Street. The downtown skyline is relatively low and is dominated by the 10-story Tiger Hotel, and the 15-story Paquin Tower.
Downtown Columbia is an area of approximately one square mile surrounded by the University of Missouri on the south, Columbia College on the north, and Stephens College to the east. The area serves as Columbia's financial and business district and is the topic of a large initiative to draw tourism, which includes plans to capitalize on the area's historic architecture, and bohemian characteristics. The city's historic residential core lies in a ring around down, extending especially to the west along Broadway, and south into the East Campus neighborhoods. Columbia can be divided into roughly 36 neighborhoods and subdivisions. The city's most dense commercial areas are primarily located along Interstate 70, U.S. Route 63, Stadium Blvd., Grindstone Blvd, and the downtown area.
In 2000, the city had a day time population of 106,487. As of the census of 2000, there were 84,531 people, 33,689 households, and 17,282 families residing in the city. The population density was 1,592.8 people per square mile (615.0/km²). There were 35,916 housing units at an average density of 676.8/sq mi (261.3/km²). The racial makeup of the city was 81.54% White, 10.85% Black or African American, 0.39% Native American, 4.30% Asian, 0.04% Pacific Islander, 0.81% from other races, and 2.07% from two or more races. 2.05% of the population were Hispanic or Latino of any race.
There were 33,689 households out of which 26.1% had children under the age of 18 living with them, 38.2% were married couples living together, 10.3% had a female householder with no husband present, and 48.7% were non-families. 33.1% of all households were made up of individuals and 6.5% had someone living alone who was 65 years of age or older. The average household size was 2.26 and the average family size was 2.92.
In the city, the population was spread out with 19.7% under the age of 18, 26.7% from 18 to 24, 28.7% from 25 to 44, 16.2% from 45 to 64, and 8.6% who were 65 years of age or older. The median age was 27 years. For every 100 females, there were 91.8 males. For every 100 females age 18 and over, there were 89.1 males.
The median income for a household in the city was $33,729, and the median income for a family was $52,288. Males had a median income of $34,710 versus $26,694 for females. The per capita income for the city was $19,507. About 9.4% of families and 19.2% of the population were below the poverty line, including 14.8% of those under age 18 and 5.2% of those age 65 or over.
The economy of Columbia is historically dominated by Education, Healthcare and the Insurance industry. Jobs in Government are also common, either in Columbia or a half-hour away in Jefferson City. Commutes into the city are also common and in 2000 the city had a day time population of 106,487. The Columbia Regional Airport and the Missouri River Port of Rocheport connect the region with trade and transportation. The University of Missouri is by far the city's largest employer.
The economy of the metro area is slightly larger than that of the Bahamas. With a Gross Metropolitan Product of $5.84 billion, Columbia's economy makes up nearly 3.0% of the Gross State Product of Missouri. Insurance corporations headquartered in Columbia include Shelter Insurance, and Columbia Insurance Group. Other organizations include the MFA Incorporated, Missouri State High School Activities Association and MFA oil. Companies such as Slackers CDs and Games and Carfax were founded in Columbia.
The Missouri Theatre Center for the Arts and Jesse Auditorium are Columbia's largest fine arts venues. The Ragtag Cinema host the well-known True/False Film Festival annually. In 2008, filmmaker Todd Sklar completed Box Elder, which was filmed entirely in and around Columbia and the University of Missouri. Every June and September, downtown Columbia is home to the Twilight Festival. The University of Missouri's Museum of Art and Archaeology displays 14,000 works of art and archaeological objects in five galleries for no charge to the public. The "We Always Swing" Jazz Series and the Roots 'n Blues 'n Barbecue Festival bring some of the country's finest Jazz and Blues to Columbia and Central Missouri.
Columbia has a flourishing and progressive music scene thanks in large part to many acts that come out of the University. The indie band White Rabbits was formed while the members were students at the University of Missouri before moving to Brooklyn to record and gain a higher profile. Musical artists from Columbia have been compiled by Painfully Midwestern Records with the ComoMusic Anthology series, and the "Das Kompilation" release. Although the hip genre continues to give Columbia some music recognition, it is their progressive psychedelic-heavy metal music scene that has garnered some attention lately. There are also local punk and hip-hop scenes that are gaining momentum locally. Country music singer-songwriter Brett James is also a native of Columbia. The song "Whiskey Bottle," by Uncle Tupelo, is rumored to be about the city of Columbia as it makes specific reference to a sign which used be displayed on a Columbia tackle shop sign which read, "Liquor, Guns, and Ammo." The sign is now displayed at the downtown location of Shakespeare's pizzeria.
The University of Missouri's sports teams the Missouri Tigers play a significant role in the sports culture of Columbia. Faurot Field, capacity 70,000, is host to both home football games and concerts. The Hearnes Center and Mizzou Arena are two other large sport and event venues. Taylor Stadium is host to the University's baseball team, the Mid-Missouri Mavericks and regional host for the 2007 NCAA Baseball Championship. Columbia College has several men and women collegiate sports teams as well. In 2007 Columbia hosted the National Association of Intercollegiate Athletics volleyball national championship which the Lady Cougars participated in.
Columbia also hosts the Show-Me State Games, a non-profit program of the Missouri Governor’s Council on Physical Fitness and Health. They are the largest state games in the United States. The games consist of 26,000–28,000 Missouri amateur athletes (35,000 total athletes) of all ages and ability levels who compete in the Olympic-style sports festival every year during July and August. It recently made ESPN's list of "101 Things All Sports Fans Must Experience Before They Die".
Situated halfway between St. Louis and Kansas City, Columbians will often have allegiances to the professional sports teams housed there such as: the St. Louis Cardinals, Kansas City Royals. St. Louis Rams, Kansas City Chiefs, and St. Louis Blues.
The city has two daily newspapers, the Columbia Missourian in the morning and the Columbia Daily Tribune in the afternoon. The Missourian is directed by professional editors and staffed by Missouri School of Journalism students who do the reporting, design, copy editing, information graphics, photography and multimedia. The Missourian is associated with the Spanish-English bilingual publication "Adelante!" and the youth oriented "Vox magazine. With a daily circulation of nearly 20,000, the Tribune is the most widely read newspaper in central Missouri. The University of Missouri has the independent but official student newspaper, The Maneater, which is printed bi-weekly.
The city has 14 radio stations and 4 television channels.
The City of Columbia's current government was established by a home rule charter adopted by voters on November 11, 1974, which established a Council-manager government that invested power in the City Council. The City Council is made up of seven members - six elected by each of Columbia's six wards, plus an at-large council member, the Mayor, who is elected by all city voters. All members of the council, none of whom receive a salary for their work, are elected to staggered three-year terms. The Mayor, in addition to being a voting member of the City Council, is recognized as the head of city government for ceremonial purposes. Chief executive authority is invested in a city manager, who oversees the day-to-day operations of government.
Columbia is the county seat of Boone County, and the county's headquarters and municipal court are located there. The City is located in the ninth U.S. Congressional district. The nineteenth Missouri State Senate district covers all of Boone County. There are five Missouri House of Representatives districts (9, 21, 23, 24, 25) in the city. Columbia is home to a plethora of attorneys and serves as a legal hub and testing grounds for many new laws and grassroot efforts.
The population generally supports progressive causes such as the extensive city recycling programs and the decriminalization of the drug cannabis both for medical and recreational use at the municipal level (though the scope of latter of the two cannabis ordinances has since been restricted). The city is also one of only four in the state to offer medical benefits to same-sex partners of city employees. The new health plan also extends health benefits to unmarried heterosexual domestic partners of city employees. On October 10, 2006, the City Council approved an ordinance to prohibit smoking in restaurants and bars. The ordinance was passed with protest, and several amendments to the ordinance reflect this.
In accordance with the Columbia Sister Cities Program, which operates in conjunction with Sister Cities International, an organization that began under President Dwight Eisenhower in 1956, Columbia has been given five international sister cities in an attempt to foster cross-cultural understanding:
Columbia and much the surrounding area lies within the The Columbia Public School District. The district enrolls over 17,000 students and has a revenue of nearly $200 million for the 2007–2008 school year. It is above the state average in attendance percentage and in graduation rate. The city operates three public high schools which cover grades 10–12: David H. Hickman High School, Rock Bridge High School, and Frederick Douglass High School. Rock Bridge High is one of two Missouri high schools to receive a silver medal by U.S. News & World Report, putting it in the top 3% of all high schools in the nation. Hickman High has been on Newsweek magazine’s list of top 1,300 schools in the country for the past three years. There are also several private high schools including: Christian Fellowship School and Columbia Independent School.
The city has three institutions of higher education. The University of Missouri, Columbia College, and Stephens College. In addition, the city is the headquarters of the University of Missouri System, which operates schools in St. Louis, Kansas City, and Rolla.
Columbia Transit operates a bus system focusing around downtown, and has been in service since 1965. Currently, 1.2 million passengers board annually along the system's eight fixed routes and two University Shuttle routes. The system is constantly experiencing growth in service and technology. A $3.5 million project to renovate and expand the Wabash Station, a rail depot built in 1910 and converted into the city's transit center in the mid-1980s, was completed in summer 2007.
The city's current mayor, Darwin Hindman, is largely in favor of a non-motorized transportation system, and can often be seen riding his bicycle around the city. Columbia is also known for its M.K.T. Spur of the Katy Trail State Park, which allows foot and bike traffic across the city, and, conceivably, the state. It consists of a soft gravel surface, excellent for running and biking. Columbia also is preparing to embark on construction of several new bike paths and street bike lanes thanks to a $25 million grant from the federal government. The city is also served by Northwest Airlines at Columbia Regional Airport, the only commercial airport in Mid-Missouri. I-70, US 63, and US 40 are the main freeways used for travel to and from Columbia. Within the city, there are three state highways Route 763, Route 163, and Route 740.
Health Care is a large sector of Columbia's economy with nearly one-in-six people working in a health-care related profession and a physician density that is about 3 times the United States average. Columbia's hospitals and supporting facilities are a large referral center for the state, and medical related trips to Columbia are common. There are three hospital systems within the city and six hospitals with a total of 1,105 beds. University of Missouri Health Care operates four hospitals: Columbia Regional Hospital, University of Missouri Hospital, Ellis Fischel Cancer Center and University of Missouri Children's Hospital. Boone Hospital Center is administered by BJC Healthcare and operates several clinics and outpatient locations. Harry S. Truman Memorial Veterans' Hospital is administered by the United States Department of Veterans Affairs.
There is also a large amount of medically-related industry in Columbia. The University of Missouri School of Medicine uses university owned facilities as teaching hospitals. The University of Missouri Research Reactor Center is the largest research reactor in the U.S. and produces radioisotopes used in nuclear medicine. The center serves as the sole supplier of the active ingredients in two FDA-approved radiopharmaceuticals and produces Fluorine-18 used in PET imaging with its cyclotron.