Colipase is a protein co-factor required for optimal
enzyme activity of
pancreatic lipase. It is secreted by the
pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by
trypsin.
Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
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