He knocked out colorful contender Tony Galento (Galento quit in the 7th round claiming to have broken his left hand).
The highlight of his boxing career occurred in his unsuccessful attempts to win the heavyweight boxing championship from Joe Louis. In their first fight, Baer caught Louis with a big left hook in the first round and knocked the champion out of the ring. Louis, however, climbed back in before the count of ten, and eventually won the fight on a disqualification. Baer claimed that he had been hit, and knocked down, after the bell in the seventh round, and refused to come out for the next round. The referee therefore disqualified him. In their rematch, Louis knocked Baer out in the first. Baer later remarked "The only way I could have beaten Louis that night was with a baseball bat."
Buddy appeared in several films. In 1949, Baer had a bit role in the Abbott and Costello romp, Africa Screams. He also appeared in Flame of Araby, Quo Vadis, Jack and the Beanstalk (another Abbott & Costello film), The Big Sky, Slightly Scarlet, Giant from the Unknown, and Snow White and the Three Stooges.
His television credits include guest roles in: Adventures of Superman, Captain Midnight, Cheyenne, Circus Boy, Climax!, Gunsmoke, Have Gun, Will Travel, Peter Gunn, Rawhide, Sky King, and Toast of the Town.
Buddy and Maxi were known as the "professional good guys" or "the genial giants". The Sacramento sports reporter Billy Conlin wrote: "When they died, the "sweet science" lost two of the sweetest!" Buddy is buried in East Lawn Sierra Hills Memorial Park, Sacramento.