Calcitriol (INN) or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH)2D3) (also known as calitrol) is the active form of vitamin D found in the body (1,25(OH)2D3). It increases the absorption of calcium and phosphate from the gastrointestinal tract and kidneys and inhibits release of calcitonin.
This is stimulated by a decrease in serum calcium and/or phosphate (PO43−), and an increase in parathyroid hormone (PTH) and/or prolactin levels. It increases blood calcium levels by increasing the absorption of calcium and phosphate from the gastrointestinal tract, increasing calcium and phosphate reabsorption in the kidneys, and inhibiting the release of calcitonin. Calcitriol acts in concert with parathyroid hormone (PTH).
Calcitriol is also sometimes used topically in the treatment of psoriasis, however the evidence to support its efficacy is inconclusive. The vitamin D analogue calcipotriol is more commonly used for psoriasis.
Calcitriol and Genistein Actions to Inhibit the Prostaglandin Pathway: Potential Combination Therapy to Treat Prostate Cancer1-3
Jan 01, 2007; Abstract We present an overview of the prostaglandin (PG) pathway as a novel target for the treatment of prostate cancer (PCa)...