c. cori

Succinate-CoA ligase (GDP-forming)

In enzymology, a succinate-CoA ligase (GDP-forming) is an enzyme that catalyzes the chemical reaction

GTP + succinate + CoA rightleftharpoons GDP + phosphate + succinyl-CoA

The 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl coenzyme A synthetase. This enzyme participates in citrate cycle (tca cycle) and propanoate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .


  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
  • Kaufman S, Gilvarg C, Cori O and Ochoa S "Enzymatic oxidation of alpha-ketoglutarate and coupled phosphorylation". J. Biol. Chem. 203 869–888.
  • Mazumder R, Sanadi DR and Rodwell WV "Purification and properties of hog kidney succinic thiokinase". J. Biol. Chem. 235 2546–2550.
  • SANADI DR, GIBSON M, AYENGAR P "Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A". Biochim. Biophys. Acta. 14 434–6.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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