, a 2-methyl-branched-chain-enoyl-CoA reductase
is an enzyme
the chemical reaction
- 2-methylbutanoyl-CoA + NAD+ 2-methylcrotonoyl-CoA + NADH + H+
Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and NAD+, whereas its 3 products are 2-methylcrotonoyl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, FAD.
- Komuniecki R, Fekete S, Thissen-Parra J "Purification and characterization of the 2-methyl branched-chain Acyl-CoA dehydrogenase, an enzyme involved in NADH-dependent enoyl-CoA reduction in anaerobic mitochondria of the nematode, Ascaris suum". J. Biol. Chem. 260 4770–7.
- Komuniecki R, McCrury J, Thissen J, Rubin N "Electron-transfer flavoprotein from anaerobic Ascaris suum mitochondria and its role in NADH-dependent 2-methyl branched-chain enoyl-CoA reduction". Biochim. Biophys. Acta. 975 127–31.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes