funny bone, highly sensitive area at the back of the elbow where the ulnar nerve passes close to the surface of the skin in a groove between end prominences of the humerus (the upper arm bone) and the ulna (the large forearm bone). A blow to the area causes the nerve to compress against bone, producing a characteristic tingling in the forearm and the last two fingers.

bone meal, finely ground bone used as a fertilizer for its content of phosphate and nitrogen (about 23%-30% available phosphate and 2%-4% nitrogen); it is an expensive form of phosphoric acid when compared with superphosphates. Bone meal is also fed to farm animals to supply needed mineral food constituents, e.g., calcium and phosphorus.

bone marrow transplant: see bone marrow.

bone marrow, soft tissue filling the spongy interiors of animal bones. Red marrow is the principal organ that forms blood cells in mammals, including humans (see blood). In children, the bones contain only red marrow. As the skeleton matures, fat-storing yellow marrow displaces red marrow in the shafts of the long bones of the limbs. In adults red marrow remains chiefly in the ribs, the vertebrae, the pelvic bones, and the skull. Erythrocytes (red blood cells), platelets, and all but one kind of leukocyte (white blood cell) are manufactured in human red marrow. The marrow releases about 10 million to 15 million new erythrocytes every second, while an equivalent number are destroyed by the spleen.

Diseases of the marrow, such as leukemia or multiple myeloma, or injury to it from metallic poisons can interfere with the production of erythrocytes, causing anemia. A bone marrow biopsy, in which a small sample of bone marrow is obtained by aspiration through a thin needle, may be used to aid in the diagnosis of leukemia, anemia, and other blood disorders, as well as to gain insight on the normal functioning of the cells of the bone marrow.

Bone marrow transplantation is a technique that infuses healthy bone marrow into a patient whose bone marrow is defective. The transplant can be autologous, consisting of bone marrow removed from the patient, treated, and then reinserted, or it can be allogeneic, consisting of healthy bone marrow obtained from a closely related donor, such as a sibling (see transplantation, medical). Bone marrow transplants are most frequently undergone for leukemia, severe forms of anemia, and disorders of the immune system. The major complications are graft-versus-host disease (as a result of allogeneic transplantation) and infections that occur before the transplanted marrow begins to produce leukocytes.

bone china, variety of porcelain developed by English potters in the last half of the 18th and early 19th cent. The clay is tempered with phosphate of lime or bone ash. This innovation greatly increased the strength of the porcelain during and after firing.

bone black, solid black material, largely carbon, produced by heating animal bones to high temperatures in the absence of air so as to drive off volatile substances. Finely divided bone black is useful as a pigment; bone char, a similar material, is an important source of activated charcoal for use in refining and decolorizing sugar.

bone, hard tissue that forms the skeleton of the body in vertebrate animals. In the very young, the skeleton is composed largely of cartilage and is therefore pliable, reducing the incidence of bone fracture and breakage in childhood. The inorganic, or mineral, content of bone is mainly calcium, phosphate and carbonate minerals. The organic content is a gelatinous material called collagen. As the body grows older, decreases in bone mass may lead to an increased vulnerability to fractures. Bone fractures heal naturally, although they are often aided through restriction of movement in the affected area. Bones assume a variety of sizes and shapes; however, all bone tissue has a three-layered composition. A spongy layer forms the interior. Long bones (such as those in the arms and legs) are hollow, the inner spaces being filled with marrow (see bone marrow), important in the formation of blood cells. Surrounding the spongy, inner layer is a hard, compact layer that functions as the basic supportive tissue of the body. The outer layer is a tough membrane called the periosteum, which sheaths most bones. Although bone appears solid, it contains numerous microscopic canals permitting the passage of blood vessels and nerve fibers. Two types of bone are present in most bones: compact, which constitutes the shaft, and cancellous, an extremely strong variety which makes up the enlarged ends of the bone. See also osteoporosis.

Long, narrow, and mountainous submarine lineation that generally separates ocean-floor ridges differing in depth by as much as 1 mi (1.6 km). The largest fracture zones, in the eastern Pacific, are more than 1,000 mi (1,600 km) long and 60–125 mi (100–200 km) wide. Numerous shorter fracture zones in the Atlantic are associated with the Mid-Atlantic Ridge.

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Break in a bone, caused by stress. It causes pain, tenderness, and inability to use the part with the fracture. The site appears deformed, swollen, and discoloured, and the bone moves in abnormal ways. It must be protected from weight bearing and movement between the broken ends while it heals, producing puttylike new tissue that hardens to join the broken pieces together. Complications include failure to heal, healing in the wrong position, and loss of function despite good healing. Fractures in joints present a particularly serious problem, often requiring surgery. Seealso osteoporosis.

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or myeloid tissue

Soft, gelatinous tissue that fills bone cavities. Red bone marrow contains stem cells, progenitor cells, percursor cells, and functional blood cells (see reticuloendothelial system). Lymphocytes mature in the lymphoid organs (see lymphoid tissue). All other blood-cell formation occurs in red marrow, which also takes part in destruction of old erythrocytes (red blood cells). Yellow bone marrow mainly stores fats. Because the leukocytes (white blood cells) produced in bone marrow are involved in immune defenses, marrow transplants can treat some types of immunodeficiency. Radiation and some anticancer drugs can damage marrow and impair immunity. Bone-marrow examination helps diagnose diseases related to blood and blood-forming organs.

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Hard-paste porcelain containing bone ash. It was developed by Josiah Spode (1754–1827) in England circa 1800. The addition of bone ash to china stone and china clay (i.e., hard china) made bone china easier to manufacture; it is stronger, does not chip easily, and has an ivory-white colour that lends itself to decoration. Other factories (Minton, Derby, Worcester, Wedgwood, Rockingham) adopted the formula in the early 19th century. Bone china remains popular for tableware in Britain and the U.S. Seealso stoneware.

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Rigid connective tissue of vertebrates, consisting of cells embedded in a hard matrix. Bones serve as the body's supporting framework, provide muscle-attachment points for movement, protect the internal organs, house the blood-cell formation system (red bone marrow), and hold about 99percnt of the calcium vital to many body processes. Bone consists of a matrix of crystals of calcium, chiefly the phosphate and carbonate, embedded among collagen fibres, providing strength and elasticity, and bone cells (less than 5percnt of its volume). An external layer of compact bone surrounds a central area of spongy bone, except at the marrow cavity. Bone does not grow by cell division; instead, different types of bone cells generate bone matrix, break it down, and maintain it. Bone is remodeled by this process, which strengthens it in areas under greatest stress, permits healing of fractures, and helps regulate calcium levels in body fluid (see calcium deficiency). The process also causes underutilized bone, as in an immobilized limb, to atrophy. Bone disorders include rheumatoid arthritis, osteoarthritis, rickets, osteoporosis, and tumours. Bone can fracture suddenly or over time, as in stress fractures.

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or osteitis deformans

Chronic bone disease of middle age. Named for James Paget, it is characterized by excessive bone destruction alternating with disordered bone construction (with dense, brittle bones and deformity that can compress internal structures). The long bones, vertebrae, pelvis, and skull are most often affected, more often in men. The risk of cancer, usually osteosarcoma, is high. Increased blood supply to the area of bone destruction may lead to heart or circulatory problems. Calcitonin (which regulates bone growth) and bisphosphonates (which block excessive bone breakdown) are drugs of treatment.

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