Formation of a blood clot (thrombus) in the heart or a blood vessel. Contributing factors include injury to a blood vessel's lining from inflammation (thrombophlebitis) or atherosclerosis, blood flow that is turbulent (e.g., from an aneurysm) or sluggish (e.g., from prolonged bed rest), or coagulation abnormalities (e.g., from high numbers of platelets or excessive fats in the blood). Thrombosis, especially in deep veins of the leg, is a particular danger after major surgery. A thrombus can block blood flow at the point of clot formation or break free to block it elsewhere (embolism).
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