In the Venture Compound, Brock instructs the Venture family to leave him and go to Spider Skull Island, to protect them from O.S.I. agents that want Brock dead. As they prepare to leave, Molotov Cocktease and her all-female hit squad, The Blackhearts, appear. Molotov describes the three assassins O.S.I. hired to kill Brock. One is Heinrich "Herr Trigger" Triggermensch, an East German bi-athlete who gets sexual pleasure from finishing off his victims. The second is Russell "Go Fish" Sturgeon, a specialist in maritime assassinations. The third is Jean-Claude Le Tueur, a big-game hunter who enjoys Silver-Age comics and exotic weapons.
At a strip club, Hunter Gathers confirms that O.S.I. is trying to kill Brock and provides him with a list of ex-O.S.I. contacts and keys to his car. As Brock leaves the strip club, he's attacked by Herr Trigger. Brock convinces Dr. Venture and Dean to depart on the X-1, but Hank stows away in the car provided by Hunter. A high-speed chase and vehicular battle ensue, which ends when the Ventures' emergency ejection seats land on and kill Herr Trigger.
The Monarch, Dr. Mrs. The Monarch, #21, #24, and the two moppets are searching the Venture compound but find it empty except for a distraught Sergeant Hatred in the bathroom. Dr. Mrs. The Monarch attempts to console him; Hatred believes his wife is going to leave him.
Brock visits two former O.S.I. agents named Shore Leave and Mile High, who have started a Scuba-based Bible Camp and changed their codenames to "Holy Diver" and "Sky Pilot". While Brock asks them for help, he is attacked by Go Fish who entangles Brock in fishing line and drags Brock behind his motorboat. As Holy Diver and Sky Pilot gear up to help, Go Fish throws chum onto Brock to attract sharks. Brock subdues a shark and then leaves his shirt and hair attached to the dead shark as a decoy. Using fishing line and two buoys, Brock rigs the shark so that it decapitates Go Fish.
Brock escorts everyone to a hotel room in Los Angeles. After Brock leaves to collect supplies, Hank strikes up a conversation with a man who turns out to be Le Tueur. Brock reappears and they begin to battle. Le Tueur is almost victorious, but Brock eventually slices him in half with his own discarded sword. Brock tells Hank to look through the list of contacts and call "The Cleaner" to dispose of Le Tueur's corpse. Moments later, two officers from the L.A.P.D. burst through the door and hold everyone at gunpoint.
Meanwhile, at the X-1, The Cocoon hovers overhead as H.E.L.P.eR. whistles in apprehension.