The comic strip takes place in a gay bed & breakfast, and features a diverse cast of regularly appearing characters, along with an ongoing flow of guests who contribute to the humor and drama. Set in the town of Northport, New York on Long Island, Kyle's Bed & Breakfast premiered in November, 1998.
The strip has addressed a range of serious topics, including gays in professional sports, gay parenting, racism, gay marriage, gays in the priesthood, AIDS, "body fascism", 9/11, people with disabilities, "straight-acting" conversion therapy, family rejection, and the struggles of married, closeted gay men.
Originally running in Genre magazine, the strip now runs in many gay and lesbian publications across North America, including the Washington Blade, the Chicago Free Press, Philadelphia Gay News, the Dallas Voice, Out New Jersey and many others.
A self-titled book collection of the comic strip, published by Kensington Books in September 2004, contains the first 5 years of the comic strip in one volume, as well as never-before published strips. It went on to become a Lambda Literary Award finalist for Best Humor Book of the Year.