The first USS Mugford (DD-105) was a Wickes-class destroyer in the United States Navy during World War I. She was named for James Mugford.
was laid down 20 December 1917
by Union Iron Works
Company, San Francisco, California
; launched 14 April 1918
; sponsored by Mrs. George H. Fort; and commissioned 25 November 1918
, Lt Comdr. John H. Everson
Mugford joined the fleet for winter exercises off Guantanamo Bay, Cuba, in January 1919, then sailed north for operations along the coast between New York and Massachusetts until 21 November, when she left Newport for San Diego, arriving 22 December. Here she became tender to a seaplane division, and during the pioneering days of naval aviation cruised with her charges on exercises along the California coast, visiting the Panama Canal Zone in December 1920 and January 1921.
She was decommissioned at San Diego 7 June 1922, and was sold for scrap to Schiavone-Bonomo Corporation, New York City in 1936.