Mike Gillespie (born May 7 1940 in Los Angeles, California) is a college baseball coach best known for leading the University of Southern California Trojans from 1987 to 2006. He coached the Trojans to the 1998 College World Series (CWS) championship.
Gillespie also played baseball at USC under coach Rod Dedeaux, and was a member of the 1961 College World Series champions. Along with Jerry Kindall, he is one of only two individuals who have both played for and coached a College World Series champion. He was succeeded as USC's head coach by Chad Kreuter, a former major league catcher who is also married to Gillespie's daughter Kelly.
In September 2007, Gillespie was named coach UC Irvine's baseball team, replacing Dave Serrano, who had just guided the Anteaters to their first CWS appearance but left to take over at Cal State Fullerton, his alma mater, after George Horton left Fullerton to head the new program at Oregon.