• Bundesstraße 52, a German road
• B-52 Stratofortress, a strategic bomber aircraft designed by Boeing
• B-52 hairstyle, a type of beehive, named after the aircraft
• The B-52's, a rock band, named after the hairstyle named after the aircraft
• B-52, a cocktail shooter named after the aircraft.

B52 may refer to:

• B52 (New York City bus) in Brooklyn
• One of the Encyclopaedia of Chess Openings codes for the Sicilian Defence in chess
• HLA-B52, is an HLA-B serotype
• Medical slang in psychiatric wards, 5 mg of haldol and 2 mg of ativan. Some places its 50 mg of benadryl instead of the haldol and sometimes 1 mg cogentin is added with the haldol to counteract the extrapyramidal side effects of the haldol. Usually given to severly agitated pateints and given I.M.