Definitions

arylamine

Arylamine N-acetyltransferase

In enzymology, an arylamine N-acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an arylamine rightleftharpoons CoA + an N-acetylarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .

References

  • CHOU TC, LIPMANN F "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 89–103.
  • Paul RC, Ratledge C "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 9–15.
  • Tabor H, Mehler AH and Stadtman ER "The enzymatic acetylation of amines". J. Biol. Chem. 204 127–138.
  • Weissbach H, Redfield BG and Axelrod J "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta 54 190–192.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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