, an arylamine N-acetyltransferase
is an enzyme
the chemical reaction
- acetyl-CoA + an arylamine CoA + an N-acetylarylamine
Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .
- CHOU TC, LIPMANN F "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 89–103.
- Paul RC, Ratledge C "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 9–15.
- Tabor H, Mehler AH and Stadtman ER "The enzymatic acetylation of amines". J. Biol. Chem. 204 127–138.
- Weissbach H, Redfield BG and Axelrod J "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta 54 190–192.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes