Arginine 2-monooxygenase

L-arginine + O₂ $rightleftharpoons$ 4-guanidinobutanamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-arginine and O₂, whereas its 3 products are 4-guanidinobutanamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-arginine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include arginine monooxygenase, arginine decarboxylase, arginine oxygenase (decarboxylating), and arginine decarboxy-oxidase. This enzyme participates in urea cycle and metabolism of amino groups. It has one cofactor: the flavin FAD.

References

• Olomucki A, Pho DB, Lebar R, Delcambe L, Thoai NV "[Arginine oxygenase (decarboxylating). V. Purification and flavin nature]". Biochim. Biophys. Acta. 151 353–66.
• Thoai NV and Olomucki A "Arginine decarboxy-oxydase. I. Caracteres et nature de l'enzyme". Biochim. Biophys. Acta 59 533–544.
• Thoai NV and Olomucki A "Arginine decarboxy-oxydase. II. Oxydation de la canavanine et de l'homoarginine en beta-guanidopropionamide et en delta-guanidovaleramide". Biochim. Biophys. Acta 59 545–552.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes